Personalized medicine. Forefront shows the schematic of the various factors that play into developing a unique phenotypic profile: genetic alterations, epigenetic modifications, clinical diagnostics, biomarker changes, and environmental changes. Upon obtaining a unique phenotypic profile, the psychiatrist is in a better position to either predict susceptibility to disease or make an accurate diagnosis. This, is in turn, allows for therapy targeted to the individual. Background: each individual will have differences in these components, giving rise to a unique phenotypic profile.