Pharmacodynamics of thiazide diuretics. This is a schematicreproduction of the kidney distal convoluted tubule. Sodiumretention is driven by basolateral Na+K+ATPase throughout the kidney . Creatine kinase (CK), reported to be high in persons ofAfrican ancestry [11, 12, 72, 73], is tightly bound near basolateralNa+K+ ATPase, where it rapidly regeneratesATP to facilitate sodium retention . Enhanced sodium retention occurs more frequently inpersons of African ancestry . Thiazide diuretics counteract this effect, albeitindirectly and partly, through inhibition of luminalNa+Cl− -cotransport.