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Table 2 Impact of immediate vs deferred initiation of antiretroviral therapy (ART) on mortality: data from randomized controlled trials involving ART-naïve HIV+ persons

From: When to start antiretroviral therapy: the need for an evidence base during early HIV infection

Study (reference)

Deaths, early ART initiationaarm

Deaths, deferred ART initiationbarm

SMART [29]

0/131

1/118

CIPRA HT-001 [30]

6/408

23/408

HPTN 052 [9]

10/886

13/877

Pooled data from the three trials

16/1,425

37/1,403

  1. aEarly ART initiation defined as start of ART at CD4 >350 cells/μl.
  2. bDeferred ART initiation defined as start of ART at CD4 <200 or <250 cells/μl.
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BMC Medicine

ISSN: 1741-7015

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