Table 1 Antigenic characterization of viral strains
Author (year) | Vaccine type | Vaccine composition | Type of laboratory-confirmed influenza used in the analysis | Circulating strains | Antigenic characterization as per author | Classification of laboratory-confirmed influenza viral strains as being matched | Classification of laboratory-confirmed influenza viral strains as being mismatched |
|---|---|---|---|---|---|---|---|
Leibovitz (1971) [24] | Other (MIV) | A/Hong Kong/Aichi/68 (H3N2) | Culture | A/Hong Kong/Aichi/68 (H3N2) | Typed by HI (cut-off: fourfold rise) to A/Hong Kong/Aichi/68, B/Massachusetts/66 | A/Hong Kong/Aichi/68 (H3N2) | NA |
Beutner (1979) [25] | Other (MIV) | A/Port Chalmers/1/73 (H3N2) | HI assay (secondary analysis) | A/Port Chalmers, A/Victoria strains | Typed by HI (cut-off: eightfold rise) to A/Port Chalmers and A/Victoria | A/Port Chalmers/1/73 (H3N2) | A/Victoria (H3N2, classified as antigenic drift) |
Rytel (1977) [26] | Other (bivalent attenuated vaccine) | A/England/42/72 (H3N2), B/Hong Kong/5/72 | Culture | A/Port Chalmers/1/73 (H3N2) | Typed by HI (cut-off: fourfold rise) to A/Hong Kong/8/66, A/England/42/72, A/Port Chalmers/1/73 | NA | A/Port Chalmers/1/73 (H3N2) (reported as antigenic drift) |
Monto (1982) [27] | Other (bivalent attenuated vaccine) | B/Ann Arbor/1/66, B/Hong Kong/8/73 | HI assay (secondary analysis) | B/Singapore/79, B/Buenos Aires/79-like | Typed by HI (cut-off: fourfold rise) to B/Hong Kong (supplied by CDC) B/Tecumseh | NA | B/Singapore/79-like, B/Buenos Aires/79-like (reported as antigenic drift) |
Tannock (1984) [28] | TIV | A/Brazil/11/78 (H1N1), A/Bangkok/I/79 (H3N2), B/Singapore/222/79 | HI assay (secondary analysis) | A/H3N2 and influenza B strains were circulating (unspecified) | Typed by HI (cut-off: fourfold rise) to A/Bangkok/1/79 | A/Bangkok/1/79 (H3N2) | NA |
Other (WV) | A/Brazil/11/78 (H1N1), A/Philippines/2/82 (H3N2), B/Singapore/222/79 | Culture | A/Victoria/7/83 (H1N1), B/USSR/100/83 | Antigenic characterization not actively performed; based on predominant epidemic viruses | NA | A/Victoria/7/83 (H1N1) B/USSR/100/83 (classified as antigenic drift) | |
Other (WV) | A/Chile/1/83 (H1N1), A/Philippine/2/82 (H3N2), B/USSR/100/83 | Culture | A/Philippines/2/82 (H3N2) | Antigenic characterization not actively performed; based on predominant epidemic viruses | A/Philippines/2/82 (H3N2) | NA | |
Other (WV) | A/Chile/1/83 (H1N1), A/Philippine/2/82 (H3N2), B/USSR/100/83 | Culture | A/Mississippi/1/85 (H3N2), B/Ann Arbor/1/86 | Antigenic characterization not actively performed; based on predominant epidemic viruses | NA | B/Ann Arbor/1/86 (classified as antigenic drift) | |
Other (WV) | A/Chile/1/83 (H1N1), A/Mississippi/1/85 (H3N2), B/Ann Arbor/1/86 (Victoria) plus A/Taiwan/1/86 (H1N1, monovalent supplement) | Culture | A/Taiwan/1/86 (H1N1) | Antigenic characterization not actively performed; based on predominant epidemic viruses | A/Taiwan/1/86 (H1N1) | NA | |
Other (WV) | A/Leningrad/360/86 (H3N2), A/Taiwan/1/86 (H1N1), B/Ann Arbor/1/86 (Victoria) | Culture | A/Sichuan/1/87 (H3N2)B/Victoria/2/87 (Victoria) | Antigenic characterization not actively performed; based on predominant epidemic viruses | NA | A/Sichuan/1/87 (H3N2), B/Victoria/2/87 (classified as antigenic drift | |
Gruber (1990) [30] | TIV | A/Chile/1/83 (H1N1), A/Philippines/2/82 (H3N2), B/USSR/100/83 (lineage unknown) | Culture or HI assay (secondary analysis) | B/Ann Arbor/1/86 (Victoria) | Typed by HI (cut-off: fourfold rise) to A/Chile, A/Philippines, A/Dunedin, A/Panama B/Ann Arbor, B/USSR | NA | B/Ann Arbor/1/86 (reported as antigenic drift) |
Edwards (1994) Y1 [31] | LAIV, TIV | LAIV: A/Texas/1/85 (H1N1), A/Bethesda/1/85 (H3N2); TIV: A/Chile/1/83 (H1N1), A/Mississippi/1/85 (H3N2), B/Ann Arbor/1/86 | Culture | A/Taiwan/1/86 (H1N1) | Typed by HI (cut-off: fourfold rise) by to the circulating strains and strains in the vaccine (supplied by CDC) | NA | A/Taiwan/1/86 (H1N1) (reported as antigenic drift) |
Edwards (1994) Y2 [31] | LAIV, TIV | LAIV: A/Kawasaki/9/86 (H1N1), A/Bethesda/1/85 (H3N2); TIV: A/Taiwan/1/86 (H1N1), A/Leningrad/360/86 (H3N2), B/Ann Arbor/1/86 | Culture | A/Sichuan/2/87 (H3N2), B/Victoria/2/87 (Victoria) | Typed by HI (cut-off: fourfold rise) by to the circulating strains and strains in the vaccine (supplied by CDC) | NA | A/Sichuan/2/87 (H3N2) (reported as antigenic drift) |
Edwards (1994) Y3 [31] | LAIV, TIV | LAIV: A/Kawasaki/9/86 (H1N1), A/Los Angeles/2/87 (H3N2); other: A/Taiwan/1/86 (H1N1), A/Sichuan/2/87 (H3N2), B/Beijing/1/87 | Culture | A/Taiwan/1/86 (H1N1), B/Yamagata/16/88 (Yamagata) | Typed by HI (cut-off: fourfold rise) by to the circulating strains and strains in the vaccine (supplied by CDC) | A/Taiwan/1/86 (H1N1) | NA |
Edwards (1994) Y4 [31] | LAIV, TIV | LAIV: A/Kawasaki/9/86 (H1N1), A/Los Angeles/2/87 (H3N2); TIV: A/Taiwan/1/86 (H1N1), A/Shanghai/11/87 (H3N2), B/Yamagata/16/88 | Culture | A/Shanghai/11/87 (H3N2) | Typed by HI (cut-off: fourfold rise) by to the circulating strains and strains in the vaccine (supplied by CDC) | A/Shanghai/11/87 (H3N2) | NA |
Clover (1991) [32] | TIV, Other (Bivalent CR) | TIV: A/Chile/83 (H1N1), A/Mississippi/85 (H3N2), B/Ann Arbor/8 (Victoria); bivalent CR: A/Texas/1/85 (H1N1), A/Bethesda/1/85 (H3N2) | Viral culture or HI assay (secondary analysis) | A/Taiwan/1/86 (H1N1) closely related to A/Singapore/6/86 (H1N1), A/Chile/1/83 (H1N1) | Typed by HI (cut-off: eightfold rise or two ≥fourfold rises) to A/Chile and A/Taiwan | NA | A/Taiwan/1/86-like (H1N1) |
Govaert (1994) [33] | Other (purified split viron vaccine) | A/Singapore/6/86 (H1N1), A/Beijing/353/89 (H3N2), B/Beijing/1/87 (Victoria), B/Panama/45/90 (Yamagata) | HI assay (secondary analysis) | A/Beijing/353/89 (H3N2), A/Singapore/6/86 (H1N1), B/Beijing/1/87 (Victoria), B/Panama/45/90 (Yamagata) | Antigenic characterization not actively performed; based on predominant epidemic viruses | A/Beijing/353/89 (H3N2) | NA |
Powers (1995) [34] | TIV | A/Texas/36/91 (H1N1), A/Beijing/32/92 (H3N2), B/Panama/45/90 (Yamagata) | Culture or HI assay (secondary analysis) | A/Beijing/32/92 (H3N2) | Type by HI (cut-off: fourfold rise) to A/Beijing (supplied by CDC) | A/Beijing/32/92 (H3N2) | NA |
Belshe (1998) [35] | LAIV | A/Texas/36/91-like (H1N1), A/Wuhan/359/95-like (H3N2), B/Harbin/7/94-like (Yamagata) | Culture | Influenza A (H3N2), influenza B. The isolation of influenza A or B among the study population paralleled that in the community in general. | Typed by HI (cut-off: fourfold rise) to A/Texas, A/Wuhan, B/Harbin | A/Wuhan/359/95-like (H3N2), B/Harbin/7/94-like (Yamagata) | NA |
Rudenko (2001) [36] | LAIV, TIV | LAIV: A/Leningrad/134/17/57 (H3N2) or A/Texas/36/91(H1N1), A/Nanchang/933/95 (H3N2), B/Harbin/07/94 (Yamagata), B/Ann Arbor/1/86 (Victoria); TIV: A/Texas/36/91 (H1N1), A/Nanchang/933/95 (H3N2), B/Harbin/07/94 (Yamagata) | Culture or HI assay (secondary analysis) | Viral isolates similar to A/Texas/36/91 (H1N1), or B/Harbin/07/94 | Typed by HI (cut-off: fourfold rise) to vaccine strains | A/Texas/36/91 (H1N1), B/Harbin/07/94 (Yamagata) | NA |
Belshe (2000) [37] | LAIV | A/Shenzhen/227/95-like (H1N1), A/Wuhan/359/95 (H3N2), B/Harbin/7/94-like | Culture | A/Sydney/5/97-like; A/Wuhan/359/95-like and Influenza B | Typed by HI (cut-off: fourfold rise) to A/Nanchang (similar to A/Wuhan) and A/Sydney | A/Wuhan/359/95-like (H3N2) | A/Sydney/5/97-like (H3N2) (reported as antigenic drift) |
Bridges (2000) Y1 [38] | TIV | A/Johannesburg/82/96 (H1N1), A/Nanchang/933/95 (H3N2), B/Harbin/7/94 (Yamagata) | Culture or HI assay (secondary analysis) | A/Sydney/5/97-like (H3N2), A/Michigan/8/98 (H3N2) | Typed by HI (cut-off: fourfold rise) to A/Johannesburg, A/Nanchang, B/Harbin, A/Sydney, A/Michigan (supplied by CDC) | A/Sydney/5/97-like (H3N2) (reported as antigenic drift) | |
Bridges (2000) Y2 [38] | TIV | A/Beijing/262/95 (H1N1), A/Sydney/5/97 (H3N2), and B/Harbin/7/94 (Yamagata) | Culture or HI assay (secondary analysis) | A/Sydney/5/97-like (H3N2), B/Beijing/184/93-like (Yamagata) | Typed by HI (cut-off: fourfold rise) to A/Johannesburg, A/Nanchang, B/Harbin, A/Sydney, A/Michigan (supplied by CDC) | A/Sydney/5/97-like (H3N2) B/Beijing/184/93-like (Yamagata) | NA |
Hoberman (2003) Y1 [39] | TIV | A/Beijing/262/95 (H1N1), A/Sydney/15/97 (H3N2), and B/Yamanashi/166/98 (Yamagata) | Culture | A/Beijing/262/95 (H1N1), A/Sydney/15/97 (H3N2) | Typed by HI (cut-off: fourfold rise) to A/Beijing and A/Sydney | A/Beijing/262/95 (H1N1), A/Sydney/15/97 (H3N2) | NA |
Hoberman (2003) Y2 [39] | TIV | A/New Caledonia/20/99 (H1N1), A/Panama/07/99 (H3N2), and B/Yamanashi/166/98 (Yamagata) | Culture | A/New Caledonia/20/99 (H1N1), A/Panama/07/99 (H3N2) B/Yamanashi/166/98 (Yamagata) | Typed by HI (cut-off: fourfold rise) to A/New Caledonia, B/Yamanashi, A/Panama | A/New Caledonia/20/99 (H1N1), A/Panama/07/99 (H3N2), B/Yamanashi/166/98 (Yamagata) | NA |
Tam (2007) Y1 [40] | LAIV | A/New Caledonia/20/99 (H1N1), A/Sydney/05/97 (H3N2), B/Yamanashi/166/98 (Yamagata) | Culture | B/Sichuan/379/99 (Yamagata), B/Hong Kong/330/01-like (Victoria) (reported in Belshe review [59]) | Typed by HI (cut-off: fourfold rise) to A/New Caledonia, A/Sydney, B/Yamanashi (supplied by the CDC) | Influenza A strains antigenically similar to vaccine (strains unspecified) | B/Sichuan-like (reported as antigenic drift), B/Hong Kong-like (classified as lineage mismatch as per Belshe review [59]) |
Tam (2007) Y2 [40] | LAIV | A/New Caledonia/20/99 (H1N1), A/Panama/2007/99 (H3N2), and B/Yamanashi/166/98 (Yamagata) | Culture | B/Victoria/504/00 (Victoria lineage) (B/Sichuan/379/99-like) virus (Yamagata) | Typed by HI (cut-off: fourfold rise) to A/New Caledonia/20/9 A/Sydney/5/97, B/Victoria/2/87 (supplied by CDC) | NA | B/Sichuan-like (reported as antigenic drift), B/Hong Kong-like (classified as lineage mismatch as per Belshe review [59]) |
Vesikari (2006) Y1 [41] | LAIV | A/New Caledonia/20/99 (H1N1), A/Sydney/05/97 (H3N2), B/Yamanashi/166/98 (Yamagata) | Culture | A/New Caledonia/20/99-like (H1N1) A/Panama/07/99-like (H3N2) B/Sichuan/379/99-like (Yamagata) | Typed by HI (cut-off NR) to vaccine strains and community acquired strains | A/New Caledonia/20/99-like (H1N1), A/Panama/07/99-like (H3N2) | Influenza A strains (unspecified; reported as antigenic drift), B/Sichuan-like (classified as antigenic drift as per Belshe review [59]), influenza B strains (unspecified; reported as lineage mismatch) |
Vesikari (2006) Y2 [41] | LAIV | A/New Caledonia/20/99 (H1N1), A/Panama/07/99 (H3N2), B/Victoria/504/00 (Yamagata) | Culture | A/New Caledonia/20/99-like (H1N1), A/Panama/07/99-like (H3N2), B/Hong Kong/330/01-like (Victoria) | Typed by HI (cut-off NR) to vaccine strains and community acquired strains | A/New Caledonia/20/99-like (H1N1), A/Panama/2007/99-like (H3N2), B/Victoria/504/00-like (Yamagata) | B/Hong Kong-like (reported as lineage mismatch) |
Forrest (2008) [42] | LAIV | A/New Caledonia/20/99-like (H1N1), A/Panama strain (H3N2), B/Victoria/504/00 (Yamagata) | Culture | A/New Caledonia/20/99 (H1N1), A/Fujian/411-02-like, B/Hong Kong/330/01-like (Victoria) | Typed by HI (cut-off: fourfold rise) to vaccine strains and community acquired strains | Antigenically similar strains to H3N2 (unspecified) | Influenza B strains (unspecified; reported as lineage mismatch) |
Bracco Neto (2009) Y1b[10] | LAIV | A/New Caledonia/20/99 -like (H1N1), A/Moscow/10/99-like (H3N2), B/Sichuan/379/99-like (Yamagata) | Culture | A/New Caledonia/20/99 (H1N1), A/Panama/07/99-like (H3N2), B/Sichuan/379/99-like (Yamagata) | Typed by HI (cut-off: fourfold rise) to vaccine strains and community acquired strains (unspecified) | A/New Caledonia/20/99-like (H1N1), A/Panama/2007/99-like (H3N2), B/Yamanashi/166/98-like (Yamagata), B/Victoria/504/00-like (Yamagata) | Influenza A strains (unspecified; reported as antigenic drift), influenza B strains (unspecified; reported as lineage mismatch) |
Bracco Neto (2009) Y2b[10] | LAIV | A/New Caledonia/20/99 (H1N1) A/Moscow/10/99 (H3N2), B/Hong Kong/330/01-like (Victoria) | Culture | A/New Caledonia/20/99 (H1N1), A/Panama/07/99-like (H3N2) B/Hong Kong/330/01-like (Victoria) | Typed by HI (cut-off: fourfold rise) to vaccine strains and community acquired strains (unspecified) | A/New Caledonia/20/99-like, A/Panama/07/99-like, B/Victoria-like (Victoria) | B/Hong Kong (reported as lineage mismatch) |
Lum (2010) [43] | LAIV | A/New Caledonia/20/99 (H1N1), A/Panama/07/99 (H3N2), B/Hong Kong/330/2001 (Victoria) | Culture | A/New Caledonia/20/99-like (H1N1), A/Panama/07/99-like (H3N2), A/Fujian/411-02-like (H3N2) in Asian regions, B/Victoria-like (Victoria) | Typed by HI (cut-off: fourfold rise) and PCR sequencing to A/Fujian/411/02-like, B/Victoria/504/00-like, A/New Caledonia/20/99-like, A/Panama/2007/99-like, B/Hong Kong/1351/02-like (supplied by CDC and Wyeth) | A/New Caledonia-like (H1N1), A/Panama-like (H3N2), B/Hong Kong-like (Victoria) | A/Fujian-like and B/Victoria-like (Victoria) (report as antigenic drift) |
Langley (2011) [44] | TIV | A/New/Caledonia/20/99 (H1N1), A/Panama/07/99 (H3N2) B/Shangdong/7/97 (Victoria) | Culture | A/New Caledonia/20/99 (H1N1)-like. A/Fujian (H3N2), B/Hong Kong/330/01-like (Victoria), B/Sichuan/379/99-like (Yamagata) | Typed by HI (cut-off: fourfold rise) (not specified) | A/Fujian (reported as antigenic drift accounting for 96.8% of H3N2 isolates) | |
Ohmit (2006)b[11] | LAIV, TIV | LAIV: A/New Caledonia/20/99 (H1N1), A/Wyoming/03/03-like (H3N2), B/Jilian/20/03-like (Yamagata lineage); TIV: A/New Caledonia/20/99 (H1N1), A/Wyoming/3/03 (H3N2), B/Jiangsu/10/03-like (Yamagata lineage) | Culture | A/California/07/04-like, A/Wisconsin-like (H3N2), B/Hawaii/33/04-like (Victoria lineage) | Typed by HI (cut-off: fourfold rise) to vaccine strains and A/California/07/04, B/Hawaii/33/04-like (supplied by the CDC) | B/Shanghai/361/02-like (Yamagata) | A/California/07/04-like (H3N2) (report as antigenic drift), B/Hawaii/33/04-like (report as lineage mismatch) |
Treanor (2007)b[12] | Other (purified rHAO vaccine) | A/New Caledonia/20/99 (H1N1), A/Wyoming/3/03 (H3N2), B/Jiangsu/10/03 (Yamagata lineage) | Culture | A/California/7/04 -like (H3N2), A/Wisconsin-like (H3N2), B/Yamagata/16/88-like (Yamagata) | Typed by HI (cut-off: fourfold rise) to vaccine and circulating strains (unspecified) (supplied by CDC) | NA | A/California-like (H3N2, report as antigenic drift), B/Yamagata-like (report as lineage mismatch) |
Beran (2009) [45] | TIV | A/New Caledonia/20/99 IVR-116 virus (H1N1), A/New York/55/04 X-157 (H3N2) B/Jiangsu/10/03 (Yamagata lineage) | Culture | A/New Caledonia/20/99 (H1N1), A/California,//07/04-like, B/Jiangsu/10/2003-like viruses (Yamagata lineage) | Typed by HI (cut-off: fourfold rise) to unspecified strains | A/California-like (H3N2), A/New Caledonia-like (H1N1), A/Czech Republic-like (H1N1) | B/Hong Kong-like, (reported as lineage mismatch) |
Jackson (2010) Y1 [15] | TIV | A/New Caledonia/20/99 (H1N1), A/New York/55/04 (H3N2), B/Jiangsu/10/03 (Yamagata lineage) | Culture | A/New Caledonia/20/99 A (H1N1), A/California/07/04-like (H3N2), A/Wisconsin-like (H3N2), B/Shanghai/361/02 (Yamagata), B/Florida/07/04-like (lineage unknown) B/Ohio/1/05 (Victoria) | Typed by HI (cut-off: fourfold rise) to vaccine and circulating strains (unspecified) (supplied by CDC and WHO) | Report results for influenza A and B strains (unspecified) with ≤fourfold difference in HI titer compared to vaccine strains | Report results for influenza A and B strains (unspecified) with >fourfold difference in HI titer compared to vaccine strains |
Jackson (2010) Y2 [15] | TIV | A/New Caledonia/20/99 (H1N1), A/Wisconsin/67/05 (H3N2), B/Malaysia/2506/04 (Victoria lineage) | Culture | A/New Caledonia/20/99, A (H1N1), A/Solomon Islands/3/06 A (H1N1), A/Wisconsin/67/05 A (H3N2), B/Yamagata/16/88 (Yamagata) B/Ohio/01/05 (Victoria) | Typed by HI (cut-off: fourfold rise) to vaccine and circulating strains (unspecified) (supplied by CDC and WHO) | Report results for influenza A and B strains (unspecified) with ≤fourfold difference in HI titer compared to vaccine strains | Report results for influenza A and B strains (unspecified) with >fourfold difference in HI titer compared to vaccine strains |
Ohmit (2008)b[13] | LAIV, TIV | LAIV/TIV: A/New Caledonia/20/99 (H1N1), A/New York/55/04 (H3N2), B/Jiangsu/10/03 (Yamagata) | Culture or PCR | A/California/07/04-like (H3N2), A/Wisconsin/67/05 (H3N2), B/Shanghai/361/02 (Yamagata), B/Florida/07/04-like (Yamagata), B/Ohio/01/05 (Victoria) | Typed by HI (cut-off: fourfold rise) to A/Wisconsin/67/05, B/Ohio/01/05, and vaccine strains | A/California/07/04 (H3N2) | B/Ohio/01/05-like (reported as lineage mismatch) |
Beran (2009) [46] | TIV | A/New Caledonia/20/99 IVR-116 (H1N1), A/Wisconsin/67/05 (H3N2), B/Malaysia/2506/04 (Victoria) | Culture | A/New Caledonia/20/99, A/Wisconsin/67/05, B/Yamagata-like (Yamagata) | Typed by HI (cut-off: fourfold rise) to unspecified strains (supplied by CDC and WHO) | A/Wisconsin (H3N2) | A/H1N1 strains (unspecified; reported as antigenic drift), B/Yamagata-like (reported as lineage mismatch) |
Monto (2009)b[14] | LAIV, TIV | LAIV/TIV: A/Solomon Islands/3/06 (H1N1), A/Wisconsin/67/05 (H3N2), B/Malaysia/2506/04 (Victoria) | PCR | A/Brisbane/59/07-like (H1N1), A/Wisconsin/67/05 (H3N2) | Typed by HI (cut-off: eightfold rise) to vaccine strains and circulating strains (supplied by CDC) | A/Wisconsin-like (H3N2) | A/Brisbane-like (report as antigenic drift), B/Yamagata-like (reported as lineage mismatch) |
Frey (2010) [47] | LAIV, TIV | LAIV/TIV: A/Solomon Islands/3/06 (H1N1)-like, A/Wisconsin/67/05 (H3N2)-like, B/Malaysia/2506/04-like (Victoria) | Culture | A/Solomon Islands/3/06 (H1N1) A/Brisbane/59/07-like (H3N2) A/Wisconsin/67/05-like (H3N2), B/Florida/4/06 (Yamagata), B/Ohio/01/05 (Victoria), B/Malaysia/2506/04 (Victoria) | Typed by HI (cut-off: fourfold rise) to unspecified strains (supplied by CDC) | Report results for influenza A (H1N1, H3N2) and B strains (unspecified) with ≤fourfold difference in HI titer compared to vaccine strain | Report results for influenza A (H1N1, H3N2) and B strains (unspecified) with >fourfold difference in HI titer compared to vaccine strain |
Treanor (2011) [48] | Other (FluBlok®) | A/Solomon Island/3/06 (H1N1), A/Wisconsin/67/05 (H3N2), B/Malaysia/2506/04 (Victoria) | Culture | A/Brisbane/59/07 (H1N1), A/Brisbane/10/07 (H3N2), B/Florida/04/06 (Yamagata) | Typed by HI (cut-off: fourfold rise) to strains (unspecified) | A/Wisconsin/67/05-like (H3N2) | A/Brisbane/59/07-like (H1N1) (reported as antigenic drift), B/Florida/04/06 (reported as lineage mismatch) (data NR by treatment group) |
Barrett (2011) [49] | TIV | A/Brisbane/59/07 (H1N1), A/Uruguay/716/07, B/Florida/4/06 (Yamagata) | Culture or RT-PCR | A/Brisbane/59/07 B/Florida/04/06 (Yamagata) B/Victoria/02/87 (Victoria) | Typed by HI (lowest titer at which the sum of the specificity and sensitivity was maximum) to strains (unspecified) (supplied by CDC) | A/Brisbane/59/07 (H1N1), A/Uruguay/716/07 (H3N2), B/Florida/4/06 | Influenza A strains (unspecified), B/Victoria-like (reported as lineage mismatch) |
Cowling (2010) [50] | TIV | A/Brisbane/59/07 (H1N1)-like, A/Brisbane/10/07 (H3N2)-like, and B/Florida/4/06 (Yamagata) | RT-PCR | A/Perth/16/09-like (H3N2) | Typed by HI (cut-off: fourfold rise) to A/Brisbane (H1N1), A/Brisbane (H3N2), A/California, A/Perth, H1N1 and B/Florida | A/Brisbane (H1N1), A/Brisbane (H3N2), A/California, and B/Florida | A/Perth/16/09-like (H3N2) (report as antigenic drift) and pandemic A/H1N1 |
Talaat (2010) [51] | Other (MIV) | A/H1N1/2009 | RT-PCR | H1N1 | Typed by HI (cut-off: fourfold rise) to A/H1N1/09 | NA | A/H1N1 (HIN1) |