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Table 1 Age-distribution of people in exposure cohorts, percentage who were female, and numbers in reference cohort 1

From: Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies

Exposure condition

Age at admission

N in the exposure cohort (% of total)

% female

Number in the reference cohort2

Rickets, osteomalacia, or vitamin D deficiency, all combined:

<15

745 (7.5)

53.0

889,364

15 to 44

532 (24)

72.4

2,906,048

45 to 64

1,191 (26.7)

70.4

2,206,093

65 to 74

1,356 (15.1)

68.9

1,198,951

75+

1,697 (26.7)

73.1

1,403,767

All ages

19,338 (100)

70.1

8,604,223

Rickets:

<15

494 (54.8)

48.9

889,495

15 to 44

73 (16.8)

70.4

2,907,044

45 to 64

32 (8.7)

71.0

2,207,541

65 to 74

29 (7)

68.6

1,200,051

75+

42 (12.7)

78.2

1,405,341

All ages

1,228 (100)

59.5

8,609,472

Osteomalacia:

<15

1 (0.1)

0.0

889,562

15 to 44

39 (16.9)

68.8

2,906,823

45 to 64

275 (30.3)

62.7

2,207,108

65 to 74

503 (20.5)

68.3

1,199,703

75+

585 (32.2)

76.7

1,404,882

All ages

5,191 (100)

69.4

8,608,078

Vitamin D deficiency:

<15

263 (6)

56.8

889,428

15 to 44

436 (27.5)

73.5

2,906,311

45 to 64

911 (26.9)

74.0

2,206,566

65 to 74

847 (13.8)

69.5

1,199,332

75+

1,107 (25.8)

71.5

1,404,315

 

All ages

13,260 (100)

71.5

8,605,952

  1. 1 The reference cohort consisted of people admitted with the following conditions coded under the Office of Population, Censuses and Surveys (OPCS) code edition 4 for operations and ICD10 code for diagnosis (with equivalent codes used for other coding editions): appendectomy (OPCS4 H01 to H03), adenoidectomy (E20), tonsillectomy (F34 + F36), dilation and curettage (Q10.3 + Q11.4), total hip replacement (W37 to W39), total knee replacement (W40 to W42), squint (ICD10 H49 to H51), cataract (H25), otitis externa/media (H60 to H67), varicose veins (I83), hemorrhoids (I84), deflected septum, nasal polyp (J33 + J34.2), impacted tooth and other disorders of teeth (K00 to K03), inguinal hernia (K40), in-growing nail, toenail and other diseases of the nails (L60), sebaceous cyst (L72.1), bunion (M20.1), internal derangement of the knee (M23), dislocations, sprains and strains (S03, S13, S23, S33, S43, S53, S63, S73, S83, S93), selected limb fractures (S42, S52, S62, S82, S92), superficial injury and contusion (S00, S10, S20, S30, S40, S50, S60, S70, S80, S90), contraceptive management (Z30).
  2. 2 The numbers in the reference cohort vary slightly depending on what the exposure condition is. This is because individuals, who otherwise fulfilled the criteria for inclusion in the reference cohort, were removed from the reference cohort if they fulfilled the criteria for inclusion in the exposure cohort (see Methods).