Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial

Table 3 Changes in N-QoL scores after 12 weeks treatment with prosultiamine

Question	Before treatment	After treatment	Pvalue
Q1 Concentration	0.6 ± 1.0	0.3 ± 1.6	0.1235
Q2 Low in energy	0.9 ± 1.1	0.4 ± 0.6	0.0077
Q3 Sleep during the day	1.5 ± 1.4	1.0 ± 1.1	0.0229
Q4 Productiveness	0.7 ± 0.9	0.3 ± 0.6	0.0830
Q5 Physical activities	1.0 ± 1.2	0.5 ± 0.8	0.0505
Q6 Fluid restriction	0.8 ± 1.2	0.7 ± 0.9	0.3270
Q7 Inadequate sleep at night	1.6 ± 1.5	0.7 ± 1.0	0.0070
Q8 Disturbance of others	0.8 ± 1.9	0.5 ± 1.8	0.0277
Q9 Preoccupation with waking at night	0.6 ± 1.1	0.3 ± 0.6	0.1235
Q10 Worry over condition worsening	1.5 ± 1.5	0.8 ± 1.1	0.0032
Q11 Worried over treatment options	1.5 ± 1.6	1.0 ± 1.3	0.0303
Q12 Overall bother	1.3 ± 1.3	0.8 ± 0.8	0.0238
Q13 Overall impact on everyday life	2.6 ± 2.8	0.9 ± 1.0	0.0023
Converted overall score (Q1 to 12)	73.2 ± 21.0	85.3 ± 19.9	0.0001
Subscale scores:
Sleep/Energy (Q1 to5, 7)	74.0 ± 20.7	87.0 ± 15.0	0.0001
Bother/Concern (Q6, Q8 to12)	72.4 ± 25.7	83.7 ± 21.2	0.0028

Subjective symptoms were evaluated using the scores of the Nocturia Quality of Life (N-QoL) questionnaire [15–17]. The score ranges of each question except Q13 are from 0 to 4. The score of Q13 is from 0 to 10. Converted overall score (0–100) = 100 × total converted scores (Q1 to 12)/4 × question numbers, converted score = 4-each raw score. Subscale score (0 to 10) = 100 × total converted scores/4 × question numbers. Statistical significance was determined by the Wilcoxon signed-rank test.

ISSN: 1741-7015