Dose– response relationship between alcohol intake (g / day) and depression risk (HR and 95% CI ). Restricted cubic spline model. The PREDIMED Study 2003 to 2010. The black line represents the HR and the dashed lines represent the 95% confidence interval. Adjusted for age, smoking, physical activity (MET-min/d), total energy intake (Kcal/day), baseline body mass index (kg/m2), marital status, intervention group, recruiting center, educational level and the number of persons living at home.