Alcohol intake, wine consumption and the development of depression: the PREDIMED study

Table 4 Sensitivity analyses

	Total cases/person-years	>5 to 5 g/day
Overall	443/23,655	0.72 (0.53 to 0.98)
Energy limits: percentiles 5 to 95	403/21,681	0.78 (0.57 to 1.06)
Energy limits: percentiles 1 to 99	444/23,675	0.71 (0.53 to 0.96)
Excluding diabetics	227/11,653	0.96 (0.64 to 1.44)
Excluding participants older than 75	389/21,200	0.73 (0.56 to 1.25)
Excluding participants younger than 65	307/14,785	0.75 (0.52 to 1.06)
Depurating abstainers’ group^a	422/22,882	0.75 (0.55 to 1.02)
Including participants with prior depression at baseline	817/25,868	0.72 (0.57 to 0.90)
Updated alcohol intake assuming induction period: 1 to 2 years^b	-	0.69 (0.50 to 0.96)
Updated alcohol intake assuming induction period: 2 to 3 years^b	-	0.68 (0.47 to 1.00)

^aAfter excluding those participants who reported any alcohol intake throughout their life but not currently at baseline.
^bRepeated-measurement analysis. Relative risks (95% confidence interval) for incident depression according to yearly updated measurements of alcohol intake. Considering incident cases during the last year of every two-year follow-up interval.
The PREDIMED Study 2003 to 2010.
All adjusted for age, sex, smoking, physical activity (MET-min/d), total energy intake (Kcal/day), baseline body mass index (kg/m²), marital status, intervention group, recruiting center, educational level, the number of persons living at home and alcohol intake at baseline.

ISSN: 1741-7015