Table 1 Summary of laboratory parameters
PBO + MET (n = 137) | DAPA 2.5 mg + MET (n = 137) | DAPA 5 mg + MET (n = 137) | DAPA 10 mg + MET (n = 135) | |
|---|---|---|---|---|
Sodium (mmol/L) | ||||
n | 72 | 77 | 87 | 93 |
Baseline | 138.9 (2.3) | 138.5 (2.9) | 138.6 (2.3) | 139.1 (2.2) |
Change at week 102 | -0.04 (2.7) | 0.2 (2.8) | 0.1 (2.6) | 0.1 (2.6) |
P vs PBO + MET | 0.1434 | 0.1905 | 0.3978 | |
Potassium (mmol/L) | ||||
n | 72 | 77 | 87 | 93 |
Baseline | 4.35 (0.47) | 4.34 (0.46) | 4.37 (0.39) | 4.37 (0.43) |
Change at week 102 | -0.08 (0.55) | -0.01 (0.45) | -0.05 (0.35) | -0.07 (0.47) |
P vs PBO + MET | 0.3366 | 0.4563 | 0.9918 | |
Serum creatinine (μmol/L) | ||||
n | 72 | 77 | 88 | 93 |
Baseline | 76.9 (17.9) | 78.7 (18.1) | 79.6 (19.3) | 77.8 (17.8) |
Change at week 102 | -0.9 (10.3) | -1.8 (9.7) | -3.5 (12.7) | -2.7 (10.6) |
P vs PBO + MET | 0.9954 | 0.4720 | 0.9032 | |
Serum uric acid (μmol/L) a | ||||
n | 28 | 35 | 47 | 57 |
Baseline | 314 (79) | 322 (80) | 323 (88) | 323 (80) |
Change at week 102 | -1.78 (54.13) | -55.9 (50.32) | -46.4 (64.36) | -52.9 (64.36) |
P vs PBO + MET | 0.0054 | 0.0013 | 0.0002 | |
Blood urea nitrogen (mmol/L) | ||||
n | 72 | 77 | 88 | 93 |
Baseline | 5.33 (1.55) | 5.51 (1.41) | 5.65 (1.81) | 5.34 (1.41) |
Change at week 102 | 0.56 (1.24) | 0.70 (1.54) | 0.42 (1.87) | 0.73 (1.44) |
P vs PBO + MET | 0.2299 | 0.4169 | 0.0845 | |
Haematocrit (%) | ||||
n | 71 | 78 | 87 | 93 |
Baseline | 42.61 (3.90) | 42.38 (3.99) | 42.15 (3.59) | 42.88 (3.95) |
Change at week 102 | -1.43 (3.29) | 0.84 (2.53) | 1.35 (2.48) | 1.54 (2.78) |
P vs PBO + MET | <0.0001 | <0.0001 | <0.0001 | |
Haemoglobin (g/L) | ||||
n | 71 | 78 | 87 | 94 |
Baseline | 142.8 (13.45) | 142.5 (14.25) | 141.6 (12.19) | 143.6 (13.10) |
Change at week 102 | -4.9 (10.14) | 1.5 (7.73) | 3.1 (8.40) | 4.1 (8.84) |
P vs PBO + MET | <0.0001 | <0.0001 | <0.0001 | |
Systolic blood pressure (mm Hg) | ||||
n | 72 | 78 | 88 | 94 |
Baseline | 128 (15) | 127 (14) | 127 (14) | 126 (16) |
Change at week 102 | 1.5 (13.7) | 0.7 (16.1) | -1.1 (13.2) | -0.3 (15.0) |
P vs PBO + MET | 0.1111 | 0.0136 | 0.0067 | |
Diastolic blood pressure (mm Hg) | ||||
n | 72 | 78 | 88 | 94 |
Baseline | 81 (9) | 80 (9) | 81 (9) | 79 (10) |
Change at Week 102 | -1.0 (7.9) | -0.1 (8.1) | -1.5 (8.1) | -1.2 (10.1) |
P vs PBO + MET | 0.6605 | 0.2140 | 0.1075 |