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Table 1 Phenomenological similarities between encephalomyelitis disseminata/multiple sclerosis (MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Phenomenology

MS

ME/CFS

Disabling fatigue

Severe exercise intolerance

Mental fatigue

‘Pacing’ as an energy conservation strategy

Worsening of symptoms following exercise

Orthostatic intolerance

Gastrointestinal dysfunction

Cardiac dysrhythmias

?

Postural hypotension

Diminished cardiac response to exercise

Relapsing-remitting nature

Chronic course

Disease exacerbated by infections

Disease exacerbated by psychological stress

Disease worsened or precipitated by infections