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Table 1 Phenomenological similarities between encephalomyelitis disseminata/multiple sclerosis (MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Phenomenology MS ME/CFS
Disabling fatigue
Severe exercise intolerance
Mental fatigue
‘Pacing’ as an energy conservation strategy
Worsening of symptoms following exercise
Orthostatic intolerance
Gastrointestinal dysfunction
Cardiac dysrhythmias ?
Postural hypotension
Diminished cardiac response to exercise
Relapsing-remitting nature
Chronic course
Disease exacerbated by infections
Disease exacerbated by psychological stress
Disease worsened or precipitated by infections