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Table 1 Phenomenological similarities between encephalomyelitis disseminata/multiple sclerosis (MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics




Disabling fatigue

Severe exercise intolerance

Mental fatigue

‘Pacing’ as an energy conservation strategy

Worsening of symptoms following exercise

Orthostatic intolerance

Gastrointestinal dysfunction

Cardiac dysrhythmias


Postural hypotension

Diminished cardiac response to exercise

Relapsing-remitting nature

Chronic course

Disease exacerbated by infections

Disease exacerbated by psychological stress

Disease worsened or precipitated by infections