Oxidative and nitrosative stress (O+NS) | ED/MS | ME/CFS |
---|---|---|
Lipid peroxidation | ✓ | ✓ |
Increased malondialdehyde | ? | ✓ |
Elevated peroxynitrite | ✓ | ✓ |
Nitrated amino acids | ✓ | ✓ |
Elevated nitric oxide (NO) | ✓ | ✓ |
Elevated inducible NO synthase (iNOS) | ✓ | ✓ |
Raised isoprostane levels | ✓ | ✓ |
Low vitamin E | ✓ | ✓ |
Reduced levels of glutathione | ✓ | ✓ |
Low zinc levels | ✓ | ✓ |
Low coenzyme Q10 concentrations | ? | ✓ |
O+NS implicated in pathology | ✓ | ✓ |