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Table 2 Similarities in oxidative and nitrosative stress (O+NS) pathways and antioxidant levels between encephalomyelitis disseminata/multiple sclerosis (ED/MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Oxidative and nitrosative stress (O+NS) ED/MS ME/CFS
Lipid peroxidation
Increased malondialdehyde ?
Elevated peroxynitrite
Nitrated amino acids
Elevated nitric oxide (NO)
Elevated inducible NO synthase (iNOS)
Raised isoprostane levels
Low vitamin E
Reduced levels of glutathione
Low zinc levels
Low coenzyme Q10 concentrations ?
O+NS implicated in pathology