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Table 4 Similarities in autoimmune responses between encephalomyelitis disseminata/multiple sclerosis (ED/MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Autoimmune responses

ED/MS

ME/CFS

Increased numbers of B cells

Anti-nuclear antibodies

Anti-cardiolipin antibodies

Anti-phospholipid antibodies

Anti-neuronal antibodies

Anti-muscle antibodies

Anti-ganglioside antibodies

Anti-serotonin (5-hydroxytryptamine (5-HT)) antibodies

Anti-muscarinic cholinergic receptor antibodies

-

Anti-mu-opioid antibodies

-

Anti-5-HTA receptor antibodies

-

Anti-D2 receptor antibodies

-

IgM against oxidatively modified neoepitopes, for example, malondialdehyde, oleic and myristic and palmitic acid

IgM against nitrosatively modified neoepitopes, for example, NO adducts

Response to rituximab