Figure 4
Transgenerational disease in F4 generation outcross or reverse outcross offspring for both male and female germline transmission. Incidences of obesity in females (a) and in males (b), ovary disease (c), testis disease (d), kidney disease in females (e), in males (f), of the F4 generation outcross (OC) (F3 dichlorodiphenyltrichloroethane (DDT) lineage male cross with wild-type female) or reverse outcross (ROC) (F3 DDT lineage female cross with wild-type male) offspring of the control, DDT, and lower dose (LD) DDT F3 generation lineages. The number of diseased rats/total number of rats (n value) in each lineage are shown above the bar. A logistic regression analysis with P value compared to control is indicated (*P <0.05; **P <0.01; ***P <0.001).