Model type | Features | Data requirements | ||
---|---|---|---|---|
Demography | Epidemiology | Clinical | ||
Static proportionate outcomes model | Reduction in cervical cancer due to vaccination is the product of effective vaccine coverage and cervical-cancer incidence caused by vaccine-type HPV | Population structure, birth and death rates | Cervical-cancer incidence, mortality and proportion caused by HPV 16/18, by age | None |
Static progression model | Represents the natural history of disease from HPV infection to cervical cancer, usually in a single birth cohort | Population structure, birth and death rates | Cervical-cancer incidence, mortality and proportion caused by HPV 16/18, by age; female HPV prevalence and clearance by age | Uptake and efficacy of screening, diagnosis and treatment of cancer and pre-cancer |
Transmission dynamic model | Captures HPV transmission from infected to susceptible individuals in the entire population | Population structure, birth and death rates, sexual behavior | Cervical-cancer incidence, mortality and proportion caused by HPV 16/18, by age; HPV prevalence and clearance by age and sex | Uptake and efficacy of screening, diagnosis and treatment of cancer and pre-cancer |
Hybrid model | Uses a static progression model to capture disease natural history, and a dynamic model to capture infection transmission | Population structure, birth and death rates, sexual behavior | Cervical-cancer incidence, mortality and proportion caused by HPV 16/18, by age; HPV prevalence and clearance by age and sex | Uptake and efficacy of screening, diagnosis and treatment of cancer and pre-cancer |