From: Which placebo to cure depression? A thought-provoking network meta-analysis
V vs F vs P(n = 4) | V vs F (n = 8) | V vs P(n = 10) | F vs P (n = 9) | Total (n = 31) | |
---|---|---|---|---|---|
Year | (1999, 2003, 2004, 2009) | (1994, 1997, 1998, 2000, 2007) | (1993, 1996, 1997, 1998, 2004) | (1991, 1998, 2002, 2004, 2005) | (1991, 1997, 1999, 2003, 2009) |
Anxious depression (No) | 3 (75%) | 7 (88%) | 10 (100%) | 8 (89%) | 28 (90%) |
Study duration (weeks) | (6, 6, 8, 12) | (6, 8, 9, 12, 12) | (4, 6, 8, 11, 13) | (4, 6, 8, 12, 13) | (4, 6, 8, 12, 13) |
Number of follow-up visits | (6, 7, 8, 8) | (6, 6, 7, 8, 9) (NA = 1) | (5, 6, 7, 8, 8) | (3, 8, 9, 9, 9) (NA = 1) | (3, 6, 7, 8, 9) (NA = 2) |
Industry sponsorship (yes) | 4 (100%) | 8 (100%) | 10 (100%) | 8 (100%) (NA = 1) | 30 (100%) (NA = 1) |
Exclusion of placebo responders (yes) | 4 (100%) | 5 (63%) | 10 (100%) | 6 (75%) (NA = 1) | 25 (83%) (NA = 1) |
Patient type | (NA = 1) | (NA = 1) | (NA = 2) | ||
Inpatients | 1 (25%) | 2 (25%) | 1 (11%) | 1 (12.5%) | 5 (17%) |
Outpatients | 3 (75%) | 5 (63%) | 7 (78%) | 6 (75%) | 21 (73%) |
Outpatients in primary care | 0 (0%) | 1 (12%) | 1 (11%) | 1 (12.5%) | 3 (10%) |
Scale used | |||||
HDRS | 4 (100%) | 5 (63%) | 4 (40%) | 8 (89%) | 23 (74%) |
MADRS | 0 (0%) | 3 (37%) | 6 (60%) | 1 (11%) | 8 (26%) |
Type of analysis | |||||
ITT with LOCF | 4 (100%) | 8 (100%) | 10 (100%) | 8 (89%) | 30 (97%) |
Mixed model | 0 (0%) | 0 (0%) | 0 (0%) | 1 (11%) | 1 (3%) |
Initial severity (HDRS score ≥25) | 3 (75%) | 5 (63%) | 6 (60%) | 3 (37.5%) (NA = 1) | 17 (57%) (NA = 1) |