Table 1 Characteristics of patients (n = 86) with tuberculosis (TB) stratified by indices of disease severity and survival
| Â | Blood CD4 cell count | Symptom severity | C-reactive protein | Hemoglobin concentration | Vital status at 90 days | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(cells/μL) | Concentration (mg/L) | (g/dL) | |||||||||||||
|  | >200 | 101 to 200 | 0 to 100 | WHO screen negative | WHO screen positive + cough <2 weeks | WHO screen positive + cough ≥2 weeks | <20 | 20 to 60 | 61 to 200 | >200 | >11.0 | 8.0 to 11.0 | <8.0 | Alive at 90 days | Death at 90 days |
(n = 24) | (n = 28) | (n = 34) | (n = 15) | (n = 49) | (n = 22) | (n = 21) | (n = 23) | (n = 19) | (n = 23) | (n = 34) | (n = 36) | (n = 12) | (n = 80) | (n = 6) | |
Patient characteristics | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Age, median (IQR) | 32.9 (28.6 to 39.0) | 31.1 (28.2 to 35.8) | 35.5 (25.8 to 44.5) | 31.5 (28.6 to 45.9) | 33.7 (28.5 to 38.0) | 30.5 (26.6 to 39.3) | 33.7 (30.7 to 38.0) | 35.5 (28.6 to 42.5) | 35.2 (28.3 to 44.5) | 30.6 (25.5 to 35.6) | 35.3 (30.3 to 45.9) | 32.9 (26.3 to 40.5) | 27.6 (25.0 to 33.1) | 32.5 (28.4 to 38.7) | 38.6 (26.6 to 44.5) |
Female (%) | 14 (58.3) | 19 (67.9) | 22 (64.7) | 10 (66.7) | 32 (65.3) | 13 (59.1) | 13 (61.9) | 16 (69.6) | 13 (68.4) | 13 (56.5) | 14 (41.2) | 29 (80.6) | 9 (75.0) | 51 (63.8) | 4 (66.7) |
BMI, median (IQR) | 21.2 (20.1 to 24.0) | 21.0 (19.7 to 27.4) | 21.9 (18.7 to 25.9) | 22.6 (19.7 to 27.6) | 21.2 (19.3 to 25.0) | 21.0 (18.0 to 22.3) | 22.0 (20.7 to 27.1) | 22.7 (20.9 to 27.6) | 20.1 (17.7 to 22.1) | 20.6 (18.4 to 24.3) | 21.3 (20.6 to 24.5) | 21.6 (18.2 to 27.1) | 19.8 (17.8 to 24.0) | 21.3 (19.6 to 26.0) | 18.9 (17.0 to 24.0) |
History of previous TB (%) | 4 (16.7) | 8 (28.6) | 5 (14.7) | 6 (40.0) | 7 (14.3) | 4 (18.2) | 5 (23.8) | 4 (17.4) | 2 (10.5) | 6 (26.1) | 7 (20.6) | 8 (22.2) | 1 (8.3) | 16 (20.0) | 1 (16.7) |
WHO stage at enrolment | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 or 2 (%) | 16 (66.7) | 18 (64.3) | 11 (32.4) | 9 (60.0) | 27 (55.1) | 9 (40.9) | 17 (81.0) | 15 (65.2) | 4 (21.1) | 9 (39.1) | 22 (64.7) | 16 (44.4) | 3 (25.0) | 45 (56.3) | 0 |
3 or 4 (%) | 8 (33.3) | 10 (35.7) | 23 (67.7) | 6 (40.0) | 22 (44.9) | 13 (59.1) | 4 (19.1) | 8 (34.8) | 15 (79.0) | 14 (60.9) | 12 (35.3) | 20 (55.6) | 9 (75.0) | 35 (43.8) | 6 (100) |
Blood Tests | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Hemoglobin g/dL (IQR) | 11.5 (10.7 to 13.7) | 10.5 (8.5 to 12.7) | 9.4 (8.0 to 11.0) | 11.5 (10.6 to 13.4) | 10.9 (8.9 to 12.0) | 8.8 (8.0 to 11.0) | 11.7 (11.3 to 14.1) | 11.1 (8.8 to 12.3) | 10.1 (7.9 to 11.6) | 9.0 (7.9 to 10.0) | 12.5 (11.7 to 13.9) | 9.5 (8.8 to 10.6) | 7.3 (7.0 to 7.6) | 10.9 (8.8 to 12.3) | 9.9 (7.2 to 10.1) |
Absolute neutrophil count cells/μL (IQR) | 3.3 (2.5 to 4.7) | 3.2 (2.4 to 4.3) | 4.0 (2.5 to 6.7) | 2.6 (1.9 to 3.5) | 3.3 (2.4 to 5.3) | 4.7 (3.0 to 7.0) | 2.5 (1.9 to 3.3) | 3.2 (2.5 to 5.0) | 5.0 (3.4 to 6.7) | 4.3 (2.6 to 9.1) | 2.8 (2.0 to 3.5) | 3.6 (2 .8 to 5.1) | 7.2 (4.4 to 9.4) | 3.3 (2.4 to 5.2) | 4.9 (4.0 to 6.2) |
Absolute lymphocyte count, cells/μL (IQR) | 1.9 (1.6 to 2.2) | 1.9 (1.4 to 2.7) | 0.8 (0.6 to 1.3) | 1.9 (1.3 to 2.7) | 1.6 (1.1 to 2.0) | 1.1 (0.7 to 1.7) | 1.6 (1.4 to 2.7) | 1.7 (1.0 to 2.2) | 1.3 (0.6 to 1.7) | 1.4 (0.7 to 2.1) | 1.6 (1.3 to 2.3) | 1.5 (0.9 to 2.0) | 0.5 (0.4 to 1.2) | 1.6 (1.1 to 2.1) | 0.7 (0.6 to 0.7) |
CD4 cell counts (cells/μl) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Median (IQR) | 233 (211 to 275) | 143 (124 to 184) | 35 (21 to 68) | 158 (44 to 189) | 137 (68 to 213) | 109 (35 to 184) | 188 (138 to 235) | 158 (71 to 205) | 52 (21 to 205) | 102 (29 to 140) | 189 (114 to 235) | 98 (41 to 194) | 28 (16 to 107) | 139 (66 to 205) | 34 (29 to 62) |
CD4 0 to 100 | - | - | 34 (100) | 5 (33.3) | 19 (38.8) | 10 (45.5) | 3 (14.3) | 8 (34.8) | 12 (63.2) | 11 (47.8) | 8 (23.5) | 18 (50.0) | 8 (66.7) | 29 (36.3) | 5 (83.3) |
CD4 101 to 200 | - | 28 (100) | - | 7 (46.7) | 13 (26.5) | 8 (36.4) | 8 (38.1) | 8 (34.8) | 1 (5.3) | 11 (47.8) | 11 (32.4) | 9 (25.0) | 4 (33.3) | 27 (33.8) | 1 (16.7) |
CD4 >200 | 24(100) | - | - | 3 (20.0) | 17 (34.7) | 4 (18.2) | 10 (47.6) | 7 (30.4) | 6 (31.6) | 1 (4.4) | 15 (44.1) | 9 (25.0) | 0 | 24 (30.0) | 0 |
Log viral load (copies/ml) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Median (IQR) | 4.7 (4.2 to 5.0) | 4.6 (4.2 to 5.3) | 5.1 (4.7 to 5.5) | 4.7 (4.2 to 5.0) | 4.8 (4.4 to 5.3) | 4.9 (4.5 to 5.4) | 4.7 (4.4 to 4.8) | 4.7 (4.4 to 5.2) | 4.9 (4.5 to 5.6) | 5.2 (4.7 to 5.6) | 4.4 (3.9 to 4.7) | 5.1 (4.8 to 5.4) | 5.6 (5.1 to 5.7) | 4.8 (4.4 to 5.3) | 5.5 (4.9 to 5.7) |