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Table 6 Biomarker panels integrating maternal serum levels of the validated PE biomarkers

From: Integrating multiple ‘omics’ analyses identifies serological protein biomarkers for preeclampsia

PE onset

Early

Late

Panel

0

1

0

2

sFlt-1a

+

-

+

-

PIGF

+

-

+

-

HPXa

-

+

-

+

FT

-

-

-

-

ADAM12a

-

-

-

-

HP

-

-

-

+

A2M

-

-

-

-

APO-E

-

-

-

-

APO C-IIIa

-

-

-

+

APO A-I

-

+

-

+

RBP4

-

-

-

+

HB

-

-

-

-

FGA

-

-

-

-

pikachurin

-

+

-

+

Panel size

2

3

2

6

ROC AUC

1.00

1.00

0.86

1.00

p value

4.35E-4

1.43E-4

2.94E-4

3.65E-4

  1. aIndicates biomarkers up-regulated in PE. Panel 0 is the benchmark panel sFlt-1/PIGF ratio; ‘+’, selected in panel; ‘-‘, unselected.
  2. AUC: area under the curve; PE: preeclampsia; ROC: receiver operating characteristic.
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BMC Medicine

ISSN: 1741-7015

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