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Table 6 Summary of the Scottish Intercollegiate Guidelines Network (SIGN) quality assessment [19]

From: Diagnostic indicators of non-cardiovascular chest pain: a systematic review and meta-analysis

Lead author/study

1.1

1.2

1.3

1.4

1.5

1.6

1.7

1.8

1.9

1.10

1.11

1.12

1.13

2.1

Dickman [31]

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

N/A

++

Bautista [32]

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

N/A

++

Fass [33]

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

++

Pandak [34]

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

PA

PA

+

Kim [35]

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

PA

PA

++

Xia [36]

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

++

Kushinir [37]

WC

WC

AA

PA

WC

WC

WC

WC

WC

NA

NA

N/A

PA

+

Lacima [38]

WC

PA

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

+

Cooke [39]

WC

AA

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

+

Bovero [40]

WC

PA

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

+

Romand [41]

WC

AA

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

+

Abrahao [42]

WC

WC

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

++

Ho [29]

WC

PA

WC

WC

WC

WC

WC

WC

WC

NA

NA

PA

WC

+

Kim [24]

WC

WC

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

++

Hong [25]

WC

WC

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

++

Netzer [26]

WC

AA

WC

WC

WC

WC

WC

PA

WC

NA

NA

WC

WC

+

Mousavi [27]

WC

WC

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

++

Singh [28]

WC

PA

WC

WC

WC

WC

WC

AA

WC

NA

NA

WC

WC

+

Lam [30]

WC

PA

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

+

Achem [43]

WC

WC

WC

WC

WC

WC

WC

AA

WC

NA

NA

WC

WC

+

Demiryoguran [48]

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

++

Foldes-Busque [49]

WC

WC

WC

WC

WC

WC

WC

WC

AA

WC

NA

WC

N/A

++

Kujipers [47]

WC

WC

WC

WC

WC

WC

WC

WC

WC

NA

NA

WC

WC

++

Katerndahl [51]

WC

AA

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

++

Fleet [50]

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

WC

++

Stochkendahl [44]

WC

WC

WC

NA

WC

WC

PA

WC

WC

NA

NA

WC

WC

+

Manchikanti [46]

WC

WC

WC

WC

PA

PA

WC

WC

WC

WC

PA

PA

WC

+

Bosner [45]

WC

WC

WC

WC

WC

WC

WC

AA

WC

WC

AA

WC

WC

++

  1. 1.1: spectrum of patients is representative of patients who will receive the test; 1.2: selection criteria described; 1.3: reference standard is likely to classify the condition correctly; 1.4: period between reference standard and index test short enough; 1.5: whole sample received verification of diagnosis; 1.6: patients receive same reference test regardless of index test results; 1.7: reference standard independent of index test; 1.8: execution of index test described in detail; 1.9: reference standard described in detail; 1.10: index test interpreted without knowledge of result of reference test; 1.11: reference standard results interpreted without knowledge of result index test; 1.12: uninterpretable or intermediate results are reported; 1.13: explanation is provided for withdrawals; 2.1: reliability of the conclusion of the study. Risk of bias (2.1) is as follows. (++), high quality: most of the criteria have been fulfilled. If not fulfilled, the conclusions of the study are very unlikely to alter. (+), moderate quality: some criteria fulfilled. Criteria not adequately described are unlikely to alter the conclusions. (−), low quality: few or no criteria fulfilled. The conclusions are likely to alter.
  2. AA adequately addressed, N/A not applicable, NA not addressed, NR not reported, PA poorly addressed, WC well covered.