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Table 1 Major resistance pathways for currently available INSTIs

From: What if HIV were unable to develop resistance against a new therapeutic agent?

Raltegravir/Elvitegravir Dolutegravir
Y143 pathway  
Y143C  
Y143R  
T97A/Y143C  
T97A/Y143R  
L74M/T97A/Y143G  
L74M/T97A/E138A/Y143C R263K
N155H pathway  
N155H  
L74M/N155H  
E92Q/N155H  
E92Q pathway  
E92Q  
T66I/E92Q  
E92Q/S153A  
E92Q/H51Y/L768V  
Q148 pathway  
Q148H  
Q148K  
Q148R  
E138K/Q148H  
E138K/Q148K  
E138K/Q148R  
G140S/Q148H  
G140S/Q148K  
G140S/Q148R  
E138A/G140S/Y143H/Q148H  
  1. INSTIs, Integrase Strand Transfer Inhibitors.