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Table 7 Shared side effects of antiretroviral therapy (ART) and antituberculosis drugs

From: Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review

Adverse effects

Antiretroviral drugs

Antituberculosis drugs

Gastrointestinal disturbance and/or pain

AZT, ddI, PIs

RIF, INH, PZA, ethionamide, PAS, clofazamine, linezolid

Liver injury

NVP, EFV, PIs, NRTIsa

RIF, INH, PZA and many second line drugs including ethionamide, fluoroquinolones, PAS

Peripheral neuropathy

D4T, ddI

INH, ethionamide, terizidone/cycloserine, linezolid

Neuropsychiatric

EFV

Terizidone/cycloserine, ethionamide, fluoroquinolones, INH

Renal impairment

TDF

Aminoglycosides and capreomycin

Rash

NVP, EFV, ABC

Rifampicin, INH, PZA, ethambutol, streptomycin and many second line drugs including fluoroquinolones, PAS, clofazamine

Blood dyscrasias

AZT, 3TC

Linezolid, rifabutin, INH, rifampicin

Cardiac conduction abnormalities

PIs

Bedaquiline, fluoroquinolones, clofazamine

Pancreatitis

D4T, ddI

Linezolid

Lactic acidosis

D4T, ddI

Linezolid

  1. 3TC 2',3'-dideoxy-3'-thiacytidine, ABC abacavir, AZT zidovudine, D4T stavudine, ddI didanosine, EFV efavirenz, INH isoniazid, NRTIs nucleoside reverse transcriptase inhibitors, NVP nevirapine, PAS para-aminosalicylic acid, PIs protease inhibitors, PZA pyrazinamide, RIF rifampicin, TDF tenofovir.
  2. aNRTIs (especially D4T and ddI) can cause steatohepatitis.