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Table 7 Shared side effects of antiretroviral therapy (ART) and antituberculosis drugs

From: Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review

Adverse effects Antiretroviral drugs Antituberculosis drugs
Gastrointestinal disturbance and/or pain AZT, ddI, PIs RIF, INH, PZA, ethionamide, PAS, clofazamine, linezolid
Liver injury NVP, EFV, PIs, NRTIsa RIF, INH, PZA and many second line drugs including ethionamide, fluoroquinolones, PAS
Peripheral neuropathy D4T, ddI INH, ethionamide, terizidone/cycloserine, linezolid
Neuropsychiatric EFV Terizidone/cycloserine, ethionamide, fluoroquinolones, INH
Renal impairment TDF Aminoglycosides and capreomycin
Rash NVP, EFV, ABC Rifampicin, INH, PZA, ethambutol, streptomycin and many second line drugs including fluoroquinolones, PAS, clofazamine
Blood dyscrasias AZT, 3TC Linezolid, rifabutin, INH, rifampicin
Cardiac conduction abnormalities PIs Bedaquiline, fluoroquinolones, clofazamine
Pancreatitis D4T, ddI Linezolid
Lactic acidosis D4T, ddI Linezolid
  1. 3TC 2',3'-dideoxy-3'-thiacytidine, ABC abacavir, AZT zidovudine, D4T stavudine, ddI didanosine, EFV efavirenz, INH isoniazid, NRTIs nucleoside reverse transcriptase inhibitors, NVP nevirapine, PAS para-aminosalicylic acid, PIs protease inhibitors, PZA pyrazinamide, RIF rifampicin, TDF tenofovir.
  2. aNRTIs (especially D4T and ddI) can cause steatohepatitis.