Expression of hypoxia-induced mRNA in maternal blood from cases of severe fetal growth restriction (FGR). (A) Heatmap of 42 hypoxia induced genes in maternal blood sampled from controls and FGR cohort. Green indicates increased expression, red is decreased expression. (B) Hypoxia inducible factor (HIF)1α, Hif2α, adrenomedullin (Adm) and lactate dehydrogenase A (LdhA) expression in maternal blood sampled from controls (n = 30) and FGR cohort (n = 20). Mean and S.E.M. are graphed. **P <0.01 ****P <0.0001.