Figure 1

Proposed model in which epigenetic factors influence migraine pathophysiology. Different factors such as hormones, inflammation and neuronal activity can result in chromatin remodeling events affecting the expression of genes and pathways involved in the onset and progress of migraine and comorbid disorders such as depression. The hyperexcitability observed in migraine itself acts on the epigenome, thus creating a feed-forward loop resulting in chronification of migraine.