Table 2 Studies examining alterations in the expression of genes involved in GR functionality
From: Depression pathogenesis and treatment: what can we learn from blood mRNA expression?
Citation | Type of study | Sample | Gene | Clinical assessments | Main findings |
|---|---|---|---|---|---|
Katz et al. 2012 [35] | Repeated measures | 106 pregnant women with history of depression | BAG1 CDC37L1 FKBP4 FKBP5 NCOR1 NCOA1 NR3C1 HSP70 ST13 STIP1 HSP90 P23 PPP5C PPIA PPID | Diagnosis based on DSM-IV criteria SCID-I BDI | Higher expression of BAG1, FKBP5, NCOA1 and PPID during pregnancy was diminished in patients in a current depressive state. |
Cattaneo et al. 2012 [23] | Case-control and follow-up | 74 MDD 34 Controls | FKBP-4 FKBP-5 GR | Diagnosis based on DSM-IV or ICD-10 criteria SCAN | Higher expression of FKBP-5 and lower expression of GR in Patients with MDD compared with controls. Significant decrease in FKBP-5 expression and increase in GR expression after 8 weeks of antidepressant treatment (escitalopram or nortriptyline) in responders only. |
Matsubara et al. 2006 [36] | Case-control | 56 MDD 48 BPD 31 Controls | GRα GRβ | Diagnosis based on DSM-IV criteria HDRS | Lower expression of GRα in patients with MDD in a current depressive state and in remission compared with controls. Lower expression of GRα in patients with BPD in a current depressive state and in remission compared with controls. No significant differences in the expression of GRβ. |
Fujimoto et al. 2008 [37] | Case-control | 60 MDD 46 BPD 28 Controls | Glo1 | Diagnosis based on DSM-IV criteria HDRS | Lower expression of Glo1 in patients with MDD and BPD in a current depressive state compared with controls. No significant difference in expression of Glo1 in patients with MDD and BPD in a remissive state compared with controls. Expression of Glo1 correlated negatively with depression scores. |