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Table 2 Studies examining alterations in the expression of genes involved in GR functionality

From: Depression pathogenesis and treatment: what can we learn from blood mRNA expression?

Citation Type of study Sample Gene Clinical assessments Main findings
Katz et al. 2012 [35] Repeated measures 106 pregnant women with history of depression BAG1
CDC37L1
FKBP4
FKBP5
NCOR1
NCOA1
NR3C1
HSP70
ST13
STIP1
HSP90
P23
PPP5C
PPIA
PPID
Diagnosis based on DSM-IV criteria
SCID-I
BDI
Higher expression of BAG1, FKBP5, NCOA1 and PPID during pregnancy was diminished in patients in a current depressive state.
Cattaneo et al. 2012 [23] Case-control and follow-up 74 MDD
34 Controls
FKBP-4
FKBP-5
GR
Diagnosis based on DSM-IV or ICD-10 criteria
SCAN
Higher expression of FKBP-5 and lower expression of GR in Patients with MDD compared with controls.
Significant decrease in FKBP-5 expression and increase in GR expression after 8 weeks of antidepressant treatment (escitalopram or nortriptyline) in responders only.
Matsubara et al. 2006 [36] Case-control 56 MDD
48 BPD
31 Controls
GRα
GRβ
Diagnosis based on DSM-IV criteria
HDRS
Lower expression of GRα in patients with MDD in a current depressive state and in remission compared with controls.
Lower expression of GRα in patients with BPD in a current depressive state and in remission compared with controls.
No significant differences in the expression of GRβ.
Fujimoto et al. 2008 [37] Case-control 60 MDD
46 BPD
28 Controls
Glo1 Diagnosis based on DSM-IV criteria
HDRS
Lower expression of Glo1 in patients with MDD and BPD in a current depressive state compared with controls.
No significant difference in expression of Glo1 in patients with MDD and BPD in a remissive state compared with controls.
Expression of Glo1 correlated negatively with depression scores.
  1. BDI: Beck Depression Inventory; BPD: bipolar disorder; DSM-IV: Diagnostic and Statistical Manual, Fourth Edition; HAM-D: Hamilton Rating Scale for Depression; HDRS: Hamilton Depression Rating Scale; ICD-10: International Classification of Diseases - 10th revision; SCAN: Schedules for Clinical Assessment in Neuropsychiatry; SCID-I: Structured Clinical Interview for DSM-IV Axis I Disorder.