From: Depression pathogenesis and treatment: what can we learn from blood mRNA expression?
Citation | Type of study | Sample | GENE Technique | Clinical assessment | Main findings |
---|---|---|---|---|---|
Beech et al. 2010 [69] | Case-control | 20 BPD 15 Controls | Microarray | Diagnosis based on DSM-IV criteria SCID HDRS MADRS HARS YMRS | Altered expression of 1180 genes in patients with BPD compared with controls. Higher expression of 559 genes and lower expression of 621 genes. Top three functional pathways affected were the mitochondrial electron transport chain, notch signaling and NF-κβ signaling pathways. |
Segman et al. 2010 [71] | Case-control | 10 mothers with postpartum depression 10 control mothers | Microarray | Diagnosis based on DSM-IV criteria SCID EPDS | Altered expression of 73 genes in mothers with postpartum depression compared with controls mothers. Lower expression of 71 genes in mothers with postpartum depression including genes related to transcriptional activation, cell cycle and proliferation, nucleotide binding, and DNA replication and repair. |
Kalman et al. 2005 [73] | Repeated measures | 6 elderly MDD | Microarray | Diagnosis based on ICD-10 criteria BDI HAM-D GDS MMSE | Altered expression of 57 genes after 4 weeks of venlafaxine treatment when compared to baseline expression levels. Lower expression of 26 and higher expression of 31 including genes involved in cell survival, ionic homeostasis, neural plasticity, signal transduction and metabolism |
Yi et al. 2012 [74] | Case-control | 8 MDD 8 SSD 8 Controls | Microarray | Diagnosis based on DSM-IV criteria HDRS-17 | Altered expression of 149 genes in patients with MDD and 1,456 genes in patients with SDD compared with controls. Functional pathways affected included IL-2- and IL6-mediated signaling and TNF receptor signaling in patients with MDD and cytokine-cytokine receptor interactions and G protein signaling pathway in patients with SDD. |