TY - JOUR AU - Soubry, Adelheid AU - Schildkraut, Joellen M. AU - Murtha, Amy AU - Wang, Frances AU - Huang, Zhiqing AU - Bernal, Autumn AU - Kurtzberg, Joanne AU - Jirtle, Randy L. AU - Murphy, Susan K. AU - Hoyo, Cathrine PY - 2013 DA - 2013/02/06 TI - Paternal obesity is associated with IGF2hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort JO - BMC Medicine SP - 29 VL - 11 IS - 1 AB - Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic machinery. Besides in vitro environmental exposures, the possible impact on the reprogramming of methylation profiles at imprinted genes at a much earlier time point, such as during spermatogenesis or oogenesis, has not previously been considered. In this study, our aim was to determine associations between preconceptional obesity and DNA methylation profiles in the offspring, particularly at the differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene. SN - 1741-7015 UR - https://doi.org/10.1186/1741-7015-11-29 DO - 10.1186/1741-7015-11-29 ID - Soubry2013 ER -