Combined treatment improves motor function in adult mice with late-onset spinal muscular atrophy (SMA). (A) Distance traveled in the open-field test during a 60-minute period. No significant differences were observed among the treatment groups. (B) The frequency of rearing events in the first 10 minutes of the 60-minute experiment to examine this behavior independent of habituation. Mice that received combined treatment generally exhibited more rearing events, but this difference did not reach significance. (C) Average latency to fall from the rotarod for mice in response to different treatments. *P < 0.05, one-way analysis of variance (ANOVA). In all motor function tests, each circle, square or triangle represents an individual adult mouse (postnatal day (PND) 90).