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Table 1 Characteristics of placebo-controlled randomized trials giving the effects of statins on testosterone

From: The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials

Lead author/publicationyear/reference Study Participants Authors: funding and affiliations
  Setting Duration Statin and daily dose Testosterone assessment method Comments Men Women Mean age, years Health status  
       Statin/placebo (no. completed study)    
Tobert 1982 [11] Europe 4 weeks Lovastatin, multiple doses Various radio immunoassays   47/10a 0 29 Healthy volunteers Affiliations include MSD
Dobs 2000 [16] US 24 weeks Simvastatin 20/40 mg/pravastatin 40 mg Radio immunoassay   85/28 0 40 Hypercholesterolemia Affiliations include Merck
Dobs 2000 [15] US 12 weeks Simvastatin 80 mg Radio immunoassay   37/39 0 45 High LDL cholesterol Affiliations include Merck
Hyyppä 2003 [29] Finland 12 weeks Simvastatin 20 mg Direct competitive immunoassay   120/120 0 48 Hypercholesterolemia None given
Boehm 2004 [28] Germany 3 months Pravastatin 40 mg Competitive electrochemiluminescence immunoassay   6/9 4/3b 65 Hypercholesterolemia None given
Banaszewska 2007 [26] Poland 12 weeks Simvastatin 20 mg Specific chemiluminescence assay Also using OCPs 0 45/48 24 PCOS NIH and drug donations
Banaszewska 2009 [27] Poland 3 months Simvastatin 20 mg Specific electrochemiluminescence assay Also using metformin 0 37/36 25 PCOS NIH and Polish State Committee for Scientific Research
Sathyapalan 2009 [30] UK 12 weeks Atorvastatin 20 mg Chemiluminescent immunoassay   0 19/18 28 PCOS Pfizer
Kazerooni 2010 [32] Iran 12 weeks Simvastatin 20 mg Radio immunoassay Also using metformin 0 42/42 25 PCOS None
Raja-Khan 2011 [31] US 6 weeks Atorvastatin 40 mg Not given   0 9/11c 33 PCOS NIH, Penn State Univeristy, Pfizer
Rashidi 2011 [33] Iran 8 weeks Simvastatin 20 mg Chemiluminescence assay Also receiving IVF treatment 0 32/29 25 PCOS Daru Darman Pars Co.
  1. aSubjects with missing data excluded, but number excluded not clearly given; at least two from the statin arm were excluded.
  2. bData not used because of an implausible value for testosterone at study end in the placebo group.
  3. cTwo subjects with missing data excluded, but not clear from which arm(s).
  4. IVF = in vitro fertilization; MSD = Merck, Sharp and Dohme; NIH = National Institute of Health; OCP = oral contraceptives; PCOS = polycystic ovary syndrome.