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Table 5 Association of reversible metabolites with smoking status change in the prospective dataset (KORA S4 → F4)

From: Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study

  β estimate of smoking status
(95% confidence interval)
P
Men   
Arginine -0.12 (-0.18, -0.06) 1.4e-04a
Ornithine -0.16 (-0.24, -0.08) 2.1e-04a
PC aa C34:1 -0.09 (-0.15, -0.03) 3.3e-03a
PC aa C36:0 0.17 (0.09, 0.25) 6.4e-05a
PC aa C36:1 -0.12 (-0.18, -0.05) 8.5e-04a
PC aa C38:0 0.14 (0.06, 0.22) 3.0e-04a
PC aa C38:3 -0.04 (-0.11, 0.02) 1.7e-01
PC aa C40:4 -0.11 (-0.18, -0.03) 6.0e-03
PC ae C34:3 0.14 (0.06, 0.21) 3.5e-04a
PC ae C38:0 0.13 (0.05, 0.21) 1.8e-03a
PC ae C38:6 0.11 (0.04, 0.18) 1.5e-03a
PC ae C40:6 0.08 (0.01, 0.15) 2.1e-02
lysoPC a C18:2 0.03 (-0.06, 0.11) 5.2e-01
Women   
Carnitine -0.12 (-0.20, -0.05) 1.4e-03
PC aa C32:1 -0.18 (-0.32, -0.03) 2.1e-03
PC aa C36:1 -0.11 (-0.20, -0.02) 2.0e-02
PC ae C34:3 0.09 (-0.02, 0.19) 0.95
SM (OH) C22.2 0.12 (0.02, 0.22) 1.9e-02
  1. Result of smoking status on metabolite concentrations using linear mixed model for S4 → F4 longitudinal data, adjusted for age, BMI, and alcohol consumption. PC: phosphatidylcholine; aa: diacyl-; ae: acyl-alkyl-; lysoPC: acyl-phosphatidylcholine; SM (OH): hydroxysphingomyeline. a FDR<0.05.