Forest plots depicting odds ratios for specific autoimmune diseases in first degree relatives. Familial autoimmunity has to be seen as a two way relationship depending on which member of the nuclear family is the proband. Therefore, grouping meta-analysis by the disease present in FDRs is equivalent to analyzing it by the disease present in the proband. The figure shows four different analyses. From top to bottom autoimmune thyroid disease (A), type 1 diabetes mellitus (B), inflammatory bowel disease (C) and familial autoimmunity (D) assessed as an outcome. The summary effect (random effect model) is depicted as a diamond at the bottom of each analysis. The lateral points of each diamond indicate confidence intervals for this estimate. aNumbers represent different subgroups within the study.