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Table 4 Aggregation of ADs.

From: How do autoimmune diseases cluster in families? A systematic review and meta-analysis

 

Disease in probands

 

T1D

AITD

SLE

RA

MS

AD in FDRs

USA [35]

UK [36]

Colombia [37]

Spain [38]

Swed/Lith [40]

UK [33]

USA [35]

USA [35]

Latin America [42]

NL [44]

USA 1 [35]

USA 2 [45]

UK [46]

USA 3[48]

USA1 [32]

USA 2 [35]

USA 3 [87]

Greece (Multiplex) [50]

Greece (Simplex)[50]

Australia[52]

Italy (Multiplex) [53]

Italy (Simplex) [53]

Canada [54]

AITD

11.11

0.98

2.4

4.6

0.88

  

21.7

16

20

14.7

3.9

4.81

5.50

 

13,28

       

Hyperthyroidisma

     

4.2

        

3.75

 

22.1

9.42

8.2

14.15

   

Hypothyroidism a

     

7.38

           

1.71

0.74

9.43

   

T1D

  

13.5

  

7.53

78.9

39.7

 

12.53

30.9

14.49

   

74

93.2

14.41

5.41

49.65

11.70

3.51

1.93

RA

   

0.9

 

7.41

22.5

16.98

64

28.57

    

2.0

7.8

18.7

0.68

0.18

20.75

  

1.73

PA

  

2.14

  

12.38

                 

SLE

462

 

13.35

  

5.71

312.5

  

595

163.4

    

390

225

42.8

25

471

   

AdD

     

4.81

                 

CD

   

3.6

0.54

0.39

                 

VIT

  

0.8

2.75

 

1.6

           

0.86

0.09

4.72

   

MS

     

7.61

86.2

130

 

164

67.6

            

MG

     

9.13

     

9.17

     

68.49

7.09

    

IBD

   

0.89

 

1.25

30

4.2

  

21.79

   

4.44

24

 

10.9

7.38

15.09

   

PSO

14.8

  

1.6

   

10

  

15.69

   

2.67

25

 

5.48

1.77

33.9

   

SS

         

7.9

       

6.85

1.77

    

AS

           

2.29

       

56.6

   

SSc

        

500

595

         

471

   

IIM

        

400

              
  1. Table shows aggregation (λ) of ADs. The top row depicts the AD present in the proband while the first column shows the AD present in FDRs. The numbers correspond to the calculation of aggregation. aOnly autoimmune hypothyroidism and hyperthyroidism are depicted. Prevalences in the general population according to [2, 29–32]. If a range was reported the mean was calculated. AdD, Addison's disease; AS, ankylosing spondylitis; AITD, autoimmune thyroid disease; CD, celiac disease; IBD, inflammatory bowel disease; IIM, idiopathic inflammatory myositis; Lith, Lithuania; MG, myasthenia gravis; MS, multiple sclerosis; NL, The Netherlands; PA, pernicious anemia; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren's syndrome; SSc, systemic sclerosis; Swed, Sweden; T1D, type 1 diabetes; VIT, vitiligo.
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