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Table 4 Aggregation of ADs.

From: How do autoimmune diseases cluster in families? A systematic review and meta-analysis

  Disease in probands
  T1D AITD SLE RA MS
AD in FDRs USA [35] UK [36] Colombia [37] Spain [38] Swed/Lith [40] UK [33] USA [35] USA [35] Latin America [42] NL [44] USA 1 [35] USA 2 [45] UK [46] USA 3[48] USA1 [32] USA 2 [35] USA 3 [87] Greece (Multiplex) [50] Greece (Simplex)[50] Australia[52] Italy (Multiplex) [53] Italy (Simplex) [53] Canada [54]
AITD 11.11 0.98 2.4 4.6 0.88    21.7 16 20 14.7 3.9 4.81 5.50   13,28        
Hyperthyroidisma       4.2          3.75   22.1 9.42 8.2 14.15    
Hypothyroidism a       7.38             1.71 0.74 9.43    
T1D    13.5    7.53 78.9 39.7   12.53 30.9 14.49     74 93.2 14.41 5.41 49.65 11.70 3.51 1.93
RA     0.9   7.41 22.5 16.98 64 28.57      2.0 7.8 18.7 0.68 0.18 20.75    1.73
PA    2.14    12.38                  
SLE 462   13.35    5.71 312.5    595 163.4      390 225 42.8 25 471    
AdD       4.81                  
CD     3.6 0.54 0.39                  
VIT    0.8 2.75   1.6             0.86 0.09 4.72    
MS       7.61 86.2 130   164 67.6             
MG       9.13       9.17       68.49 7.09     
IBD     0.89   1.25 30 4.2    21.79     4.44 24   10.9 7.38 15.09    
PSO 14.8    1.6     10    15.69     2.67 25   5.48 1.77 33.9    
SS           7.9         6.85 1.77     
AS             2.29         56.6    
SSc          500 595           471    
IIM          400               
  1. Table shows aggregation (λ) of ADs. The top row depicts the AD present in the proband while the first column shows the AD present in FDRs. The numbers correspond to the calculation of aggregation. aOnly autoimmune hypothyroidism and hyperthyroidism are depicted. Prevalences in the general population according to [2, 2932]. If a range was reported the mean was calculated. AdD, Addison's disease; AS, ankylosing spondylitis; AITD, autoimmune thyroid disease; CD, celiac disease; IBD, inflammatory bowel disease; IIM, idiopathic inflammatory myositis; Lith, Lithuania; MG, myasthenia gravis; MS, multiple sclerosis; NL, The Netherlands; PA, pernicious anemia; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren's syndrome; SSc, systemic sclerosis; Swed, Sweden; T1D, type 1 diabetes; VIT, vitiligo.