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Table 2 Currently available measurement systems for sleep and circadian rhythms

From: Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

Measurement system

Key features

Proposed use

Self-report

Prolonged reporting (for example, two weeks or more) of sleep timing, latency, quality and duration, daily mood, daytime physical activity

- Identification of insomnia, dysfunctional sleep and circadian-rhythms.

Cross sectional questionnaires of sleep quality, excessive daytime sleepiness, fatigue, presence of sleep disordered breathing and circadian rhythms;

- Characterization of the sleep-wake cycle.

Smart phone technologies now allow daily recording of sleep schedules and disturbances, as well as daytime physical activity patterns

- Assessment of treatment response.

Polysomnography

Laboratory or ambulatory monitoring of nocturnal sleep

- Differential diagnosis of various sleep disorders.

- Characterization of sleep macro/microarchitecture.

Actigraphy

Indirect measure of the sleep-wake cycle especially convenient for multiday ambulatory assessment

- Identification of insomnia, dysfunctional sleep and circadian rhythms.

At least one week of monitoring, (including weekdays and weekends)

- Characterization of the sleep-wake cycle.

Key differentiation of patterns of sleep onset, offset, daytime activity and napping

- Assessment of treatment response.

Some monitors can simultaneously record patterns of light exposure and estimate energy expenditure

Melatonin assays

Dim light melatonin onset protocol in controlled laboratory settings or at home

- Characterization of circadian rhythms

- Assessment of treatment response.

From saliva, urine or blood

- Can support diagnosis of some circadian rhythm sleep disorders

Core body temperature monitoring

24-hour recording in controlled laboratory settings

- Characterization of circadian rhythms

- Assessment of treatment response

From ingested wireless probe or rectal probe

- Can support diagnosis of some circadian rhythm sleep disorders

Cortisol assays

24-hour recording

- Characterization of circadian rhythms

From saliva, urine or blood

- Assessment of treatment response

Vigilance monitoring

24-hour recording in controlled laboratory settings

- Characterization of circadian rhythms

- Psychomotor Vigilance Task (PVT)

- Assessment of treatment response

- Wake EEG

- Multiple Sleep Latency test

The PVT or similar tasks are now available on smart phone applications

Cardiovascular monitoring

Continuous or repeated measures of blood pressure and heart rate parameters across 24 hours in controlled laboratory settings

- Characterization of circadian rhythms

- Assessment of treatment response