Table 1 Selected non-major histocompatibility complex susceptibility genes for systemic sclerosis which were confirmed in at least two independent studies.
From: Genetics of scleroderma: implications for personalized medicine?
| Â | Approximate OR | Potential Function |
|---|---|---|
BANK1 | 1.2-1.5* | Lymphocyte activation - B cells |
BLK | 1.2-1.5 | Lymphocyte activation - B cells |
CD247 | 1.2-1.5* | Lymphocyte activation - T cells |
CD226 | 1.0-1.2 | Lymphocyte activation - T cells |
IRF5 | 1.2-1.5 | Innate immune signaling - Interferon pathway |
MIF | 1.0-1.2 | Adhesion molecule on endothelial cells |
PTPN22 | 1.2-1.5 | Lymphocyte activation - T cells |
STAT4 | 1.2-1.5 | Innate immune signaling and lymphocyte activation - T cells |
TNFSF4 | 1.2-1.5 | Lymphocyte activation - T cells and B cells |