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Table 2 Selected genes associated with various SSc disease manifestations based on case- case comparisons.

From: Genetics of scleroderma: implications for personalized medicine?

Gene Clinical Association
CTGF ILD by pulmonary function test or HRCT [27]
HGF End-stage ILD by pulmonary function test [28]
HLA-DRB1*04:07 Scleroderma Renal Crisis [38]
HLA-DRB1*13:04 Scleroderma Renal Crisis [38]
IL23R PAH by echocardiogram or right heart catheterization [33]
IRAK1 ILD by HRCT [29]
IRF5 Overall survival [26] ILD by HRCT [6, 30] Severity of ILD by pulmonary function test [26]
KCNA5 PAH by right heart catheterization [34]
MMP-12 ILD by pulmonary function test and HRCT [31]
SP-B ILD by HRCT [32]
TLR2 PAH by right heart catheterization [35]
TNFAIP3 PAH by right heart catheterization [36]
UPAR PAH by right heart catheterization [37]