Table 2 Selected genes associated with various SSc disease manifestations based on case- case comparisons.
From: Genetics of scleroderma: implications for personalized medicine?
Gene | Clinical Association |
|---|---|
CTGF | ILD by pulmonary function test or HRCT [27] |
HGF | End-stage ILD by pulmonary function test [28] |
HLA-DRB1*04:07 | Scleroderma Renal Crisis [38] |
HLA-DRB1*13:04 | Scleroderma Renal Crisis [38] |
IL23R | PAH by echocardiogram or right heart catheterization [33] |
IRAK1 | ILD by HRCT [29] |
IRF5 | Overall survival [26] Severity of ILD by pulmonary function test [26] |
KCNA5 | PAH by right heart catheterization [34] |
MMP-12 | ILD by pulmonary function test and HRCT [31] |
SP-B | ILD by HRCT [32] |
TLR2 | PAH by right heart catheterization [35] |
TNFAIP3 | PAH by right heart catheterization [36] |
UPAR | PAH by right heart catheterization [37] |