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Table 5 Oxford Record Linkage Study (ORLS) (1963 to 1998) a : rate ratios for tuberculosis (TB) in people with immune-mediated disease (IMD) and for immune-mediated disease in people with tuberculosis

From: Associations between selected immune-mediated diseases and tuberculosis: record-linkage studies

Exposure (earlier admission)

Outcome (later admission)

Observed

Expected

Rate ratio (95% CI)

Pvalue

Addison's disease

Tuberculosis

15

0.8

20.06 (11.18 to 33.27)

<0.001

Ankylosing spondylitis

Tuberculosis

6

1.6

3.87 (1.42 to 8.46)

0.002

Chronic active hepatitis

Tuberculosis

4

0.3

12.32 (3.35 to 31.66)

<0.001

Crohn's disease

Tuberculosis

18

4

4.61 (2.72 to 7.33)

<0.001

Pernicious anemia

Tuberculosis

25

11.1

2.28 (1.47 to 3.39)

<0.001

Rheumatoid arthritis

Tuberculosis

69

26.7

2.71 (2.09 to 3.46)

<0.001

SLEb

Tuberculosis

8

0.5

17.29 (7.44 to 34.22)

<0.001

Tuberculosis

Addison's diseaseb

13

1.9

7.6 (3.94 to 13.48)

<0.001

Tuberculosis

Chronic active hepatitisc

6

1.2

5.37 (1.93 to 12.07)

<0.001

Tuberculosis

Goodpasture's syndromeb

2

0.3

8.09 (0.91 to 34.08)

0.018

Tuberculosis

Myxedemab

36

23.1

1.57 (1.1 to 2.18)

0.009

Tuberculosis

SLEb

7

1.4

5.31 (2.1 to 11.21)

<0.001

Tuberculosis

Dermatomyositisb

3

0.4

8.18 (1.6 to 26.15)

0.001

  1. The table shows observed numbers of cases of TB in people with selected immune-mediated diseases, and observed numbers of cases of selected immune-mediated diseases in people with TB; expected number of cases, rate ratios and 95% confidence intervals (CIs) based on comparison with the control cohort for statistically significant comparisons. aYears 1963 to 1998 unless otherwise stated (span of years depends on whether the disease is separately identifiable in earlier editions of the International Classification of Diseases (ICD)). bCases identified from 1968 to 1998 (that is, from ICD-8 onwards). cCases identified from 1979 to 1998 (that is, from ICD-9 onwards.