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Table 1 Baseline demographic and clinical (A), echocardiographic and biochemical (B) characteristics of patients referred with suspected TB pericarditis

From: Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study

A.     
Baseline feature All study patients Definite-TB Probable-TB Non-TB
  Number = 151 Number = 74 Number = 50 Number = 27
Demographics     
Age (median, IQR) 34 (29 to 42) 33 (27 to 38)* 33 (28 to 37)* 52 (34 to 60) * P <0.001
Male (number, %) 93 (62) 48 (65) 32 (64) 13 (48)
HIV positive (number, %)a 105 (74) 59 (80)* 41 (82)* 5 (28) * P < 0.001
CD4 count (median, IQR)a 139 (81 to 249) 131 (70 to 206)* 153 (81 to 271)* 301 (229 to 424) * P = 0.04
ARV therapy (number/Number, %) 18/98 (18) 10/54 (19) 7/39 (18) 1/5(20)
Presenting clinical features     
NYHA Class I – II (number/Number, %) 77/134 (58) 39/66 (59)* 35/47 (75)* 3/21 (14) * P < 0.001
NYHA Class III – IV (number/Number, %) 57/134 (41) 27/66 (41)* 12/47 (25)* 18/21 (86) * P < 0.001
Systolic blood pressure (mean, SD) (number = 145) 113 (17) 113 (17) 112 (16) 115 (22)
Diastolic blood pressure (mean, SD) (number = 145) 72 (14) 72 (15) 72 (13) 73 (14)
Heart rate (mean, SD) (number = 146) 111 (20) 114 (22) 108 (16) 111 (21)
Serum biochemical data     
Haemoglobin g/dl (mean, SD) 9.6 (2.1) 9.4 (2.1)* 9.3 (1.7)* 10.9 (2.3) * P = 0.004
Creatinine, μmol/L (median, IQR) 73 (59 to 90) 72 (58 to 86) 77 (61 to 92) 72 (61 to 81)
Total WCC × 109/L (median, IQR) 6.5 (4.8 to 9.3) 6.5 (4.4 to 8.2)* 5.8 (4.8 to 7.2)* 10.5 (7.1 to 15.2) * P <0.001
B.     
Echocardiographic features     
Size of effusion (mm) (mean, SD) (number = 126) 36 (14) 36 (14)* 38 (13)* 29 (14) * P <0.001
Tamponade (number, %) (number = 141) 94 (67) 50 (72) 32 (64) 12 (55)
Routine pericardial fluid analyses     
ADA IU/L (median, IQR) (number = 142) 51 (34 to 75) 59 (45 to 86)* 51 (34 to 77)* 17 (11 to 27) * P <0.001
Total protein g/L (median, IQR) (number = 148) 60 (52 to 68) 59 (53 to 68) 63 (56 to 68) 56 (48 to 62)
Lactate dehydrogenase (median, IQR) (number = 135) 1419 (867 to 2305) 1553 (999 to 2800)* 1093 (725 to 1613)* 884 (442 to 2305) * P = 0.02
Total PF WCC × 109/l (Median, IQR) (number = 136) 2.1 (1.1 to 3.3) 2.0 (1.2 to 3.0) 2.2 (1.2 to 2.9) 3.0 (0.7 to 8.9)
Lymphocyte predominance (number/Number, %)b 52/107(49) 29/56 (52)* 22/34 (65)* 1/17 (6) * P <0.001
  1. aNine patients refused testing or had unknown HIV status, and four HIV-infected patients had no CD4 cell count data. bMultiple invalid results. *P values indicate significant differences between patient groups. ADA, adenosine deaminase; ARV, anti-retroviral therapy; IQR, interquartile range; NYHA, New York Heart Association; PF, pericardial fluid; SD, standard deviation; WCC, white cell count.