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Table 1 Baseline demographic and clinical (A), echocardiographic and biochemical (B) characteristics of patients referred with suspected TB pericarditis

From: Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study

A.

    

Baseline feature

All study patients

Definite-TB

Probable-TB

Non-TB

 

Number = 151

Number = 74

Number = 50

Number = 27

Demographics

    

Age (median, IQR)

34 (29 to 42)

33 (27 to 38)*

33 (28 to 37)*

52 (34 to 60) * P <0.001

Male (number, %)

93 (62)

48 (65)

32 (64)

13 (48)

HIV positive (number, %)a

105 (74)

59 (80)*

41 (82)*

5 (28) * P < 0.001

CD4 count (median, IQR)a

139 (81 to 249)

131 (70 to 206)*

153 (81 to 271)*

301 (229 to 424) * P = 0.04

ARV therapy (number/Number, %)

18/98 (18)

10/54 (19)

7/39 (18)

1/5(20)

Presenting clinical features

    

NYHA Class I – II (number/Number, %)

77/134 (58)

39/66 (59)*

35/47 (75)*

3/21 (14) * P < 0.001

NYHA Class III – IV (number/Number, %)

57/134 (41)

27/66 (41)*

12/47 (25)*

18/21 (86) * P < 0.001

Systolic blood pressure (mean, SD) (number = 145)

113 (17)

113 (17)

112 (16)

115 (22)

Diastolic blood pressure (mean, SD) (number = 145)

72 (14)

72 (15)

72 (13)

73 (14)

Heart rate (mean, SD) (number = 146)

111 (20)

114 (22)

108 (16)

111 (21)

Serum biochemical data

    

Haemoglobin g/dl (mean, SD)

9.6 (2.1)

9.4 (2.1)*

9.3 (1.7)*

10.9 (2.3) * P = 0.004

Creatinine, μmol/L (median, IQR)

73 (59 to 90)

72 (58 to 86)

77 (61 to 92)

72 (61 to 81)

Total WCC × 109/L (median, IQR)

6.5 (4.8 to 9.3)

6.5 (4.4 to 8.2)*

5.8 (4.8 to 7.2)*

10.5 (7.1 to 15.2) * P <0.001

B.

    

Echocardiographic features

    

Size of effusion (mm) (mean, SD) (number = 126)

36 (14)

36 (14)*

38 (13)*

29 (14) * P <0.001

Tamponade (number, %) (number = 141)

94 (67)

50 (72)

32 (64)

12 (55)

Routine pericardial fluid analyses

    

ADA IU/L (median, IQR) (number = 142)

51 (34 to 75)

59 (45 to 86)*

51 (34 to 77)*

17 (11 to 27) * P <0.001

Total protein g/L (median, IQR) (number = 148)

60 (52 to 68)

59 (53 to 68)

63 (56 to 68)

56 (48 to 62)

Lactate dehydrogenase (median, IQR) (number = 135)

1419 (867 to 2305)

1553 (999 to 2800)*

1093 (725 to 1613)*

884 (442 to 2305) * P = 0.02

Total PF WCC × 109/l (Median, IQR) (number = 136)

2.1 (1.1 to 3.3)

2.0 (1.2 to 3.0)

2.2 (1.2 to 2.9)

3.0 (0.7 to 8.9)

Lymphocyte predominance (number/Number, %)b

52/107(49)

29/56 (52)*

22/34 (65)*

1/17 (6) * P <0.001

  1. aNine patients refused testing or had unknown HIV status, and four HIV-infected patients had no CD4 cell count data. bMultiple invalid results. *P values indicate significant differences between patient groups. ADA, adenosine deaminase; ARV, anti-retroviral therapy; IQR, interquartile range; NYHA, New York Heart Association; PF, pericardial fluid; SD, standard deviation; WCC, white cell count.
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BMC Medicine

ISSN: 1741-7015

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