Figure 2

Monocyte activation and cytokine production following phagocytosis of merozoites. Production of intracellular TNF-α (A) and surface expression of CD69 (B) was significantly elevated in the monocytes co-incubated with malaria-immune IgG (MIG) opsonized merozoites (black solid line), while that in monocytes co-incubated with merozoites opsonized with non-immune Melbourne sera (grey solid line) was no different from baseline levels detected before phagocytosis (dark dotted line).