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Table 1 Strength of association between measures of immunity and the risk of clinical episodes of malaria in the Chonyi cohort

From: Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria

Antigen

Hazard ratio (95% CI)

Pvalue

RPI

0.25 (0.10 to 0.60)

0.002

Merozoite IgG1

1.09 (0.46 to 2.55)

0.834

Merozoite IgG3

0.53 (0.21 to 1.34)

0.185

MSP119

0.89 (0.43 to 1.87)

0.776

MSP2

0.15 (0.04 to 0.47)

0.001

MSP3

0.31 (0.11 to 0.86)

0.026

AMA1

0.25 (0.10 to 0.61)

0.002

EBA175

0.47 (0.19 to 1.14)

0.095

MSP1 block 2

0.46 (0.18 to 1.18)

0.109

  1. Hazard ratios comparing the risk of a clinical episode of malaria between children who had the top versus bottom tertile of antibody responses against each antigen. ELISA antibody responses against parasite schizont extract were highly correlated (Spearman’s rho = 0.764, P <0.001 and 0.730, P <0.001 for IgG1 and IgG3, respectively) with those against whole merozoite IgG and are not included in this table. AMA1, apical membrane antigen 1; CI, confidence interval; EBA, erythrocyte binding antigen; MSP, merozoite surface protein; RPI, relative phagocytosis index. Chonyi cohort, n = 109.
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BMC Medicine

ISSN: 1741-7015

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