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Table 1 Strength of association between measures of immunity and the risk of clinical episodes of malaria in the Chonyi cohort

From: Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria

Antigen Hazard ratio (95% CI) Pvalue
RPI 0.25 (0.10 to 0.60) 0.002
Merozoite IgG1 1.09 (0.46 to 2.55) 0.834
Merozoite IgG3 0.53 (0.21 to 1.34) 0.185
MSP119 0.89 (0.43 to 1.87) 0.776
MSP2 0.15 (0.04 to 0.47) 0.001
MSP3 0.31 (0.11 to 0.86) 0.026
AMA1 0.25 (0.10 to 0.61) 0.002
EBA175 0.47 (0.19 to 1.14) 0.095
MSP1 block 2 0.46 (0.18 to 1.18) 0.109
  1. Hazard ratios comparing the risk of a clinical episode of malaria between children who had the top versus bottom tertile of antibody responses against each antigen. ELISA antibody responses against parasite schizont extract were highly correlated (Spearman’s rho = 0.764, P <0.001 and 0.730, P <0.001 for IgG1 and IgG3, respectively) with those against whole merozoite IgG and are not included in this table. AMA1, apical membrane antigen 1; CI, confidence interval; EBA, erythrocyte binding antigen; MSP, merozoite surface protein; RPI, relative phagocytosis index. Chonyi cohort, n = 109.