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Table 2 Association of adherence to medication, patients’ evaluation of their knowledge about their treatment and conditions and QOL with TBQ global score (n = 610)

From: Adaptation and validation of the Treatment Burden Questionnaire (TBQ) in English using an internet platform

  TBQ global score, mean ± SD Spearman correlation coefficient Pvalue
Adherence to treatment assessed by the MMAS-8a    
  High and moderate adherence 37.7 ± 27.5 <0.0001
  Low adherence 61.8 ± 30.5 <0.0001
Patients’ evaluation of their knowledge of:    
Their treatmentsb    
  Sufficient 47.8 ± 30.4 <0.0001
  Insufficient 62.3 ± 31.3 <0.0001
Their conditionsb    
  Sufficient 49.3 ± 30.7 <0.0001
  Insufficient 63.0 ± 31.6 <0.0001
Quality of life assessed by the PLMQOLc    
  Physical QOL −0.39 <0.0001
  Mental QOL −0.50 <0.0001
  Social QOL −0.49 <0.0001
  Overall assessment of QOL −0.50 <0.0001
  1. PLMQOL, PatientsLikeMe Quality of Life; QOL, quality of life; TBQ, Treatment Burden Questionnaire.
  2. aHigh adherence is a score of 8; medium adherence, 6 to 7; and low adherence, <6 [24]. b‘Very sufficient’ and ‘sufficient’ was considered sufficient and ‘average’, ‘insufficient’ and ‘very insufficient’was considered insufficient.
  3. cPLMQOL assesses physical, mental and social QOL; high scores indicate better QOL, while negative correlation coefficients indicate that patients with high treatment burden have low QOL.