Adaptation and validation of the Treatment Burden Questionnaire (TBQ) in English using an internet platform

Table 2 Association of adherence to medication, patients’ evaluation of their knowledge about their treatment and conditions and QOL with TBQ global score (n = 610)

	TBQ global score, mean ± SD	Spearman correlation coefficient	Pvalue
Adherence to treatment assessed by the MMAS-8^a
High and moderate adherence	37.7 ± 27.5	–	<0.0001
Low adherence	61.8 ± 30.5	–	<0.0001
Patients’ evaluation of their knowledge of:
Their treatments^b
Sufficient	47.8 ± 30.4	–	<0.0001
Insufficient	62.3 ± 31.3	–	<0.0001
Their conditions^b
Sufficient	49.3 ± 30.7	–	<0.0001
Insufficient	63.0 ± 31.6	–	<0.0001
Quality of life assessed by the PLMQOL^c
Physical QOL	−	−0.39	<0.0001
Mental QOL	−	−0.50	<0.0001
Social QOL	−	−0.49	<0.0001
Overall assessment of QOL	−	−0.50	<0.0001

PLMQOL, PatientsLikeMe Quality of Life; QOL, quality of life; TBQ, Treatment Burden Questionnaire.
^aHigh adherence is a score of 8; medium adherence, 6 to 7; and low adherence, <6 [24]. ^b‘Very sufficient’ and ‘sufficient’ was considered sufficient and ‘average’, ‘insufficient’ and ‘very insufficient’was considered insufficient.
^cPLMQOL assesses physical, mental and social QOL; high scores indicate better QOL, while negative correlation coefficients indicate that patients with high treatment burden have low QOL.

ISSN: 1741-7015