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Table 4 Logistic regression models predicting pregnancy outcomes from metabolite levels

From: Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother–child cohort study

Outcomes Metabolite IQR 95% CI Pvalue
Min Max
All PB types (n = 114) Steroid conjugate: 0.63 (s) 1.90 0.99 3.69 0.054
  Formate 0.51 0.26 0.99 0.047
SPB (n = 88) Steroid conjugate: 0.63 (s) 1.99 0.94 4.32 0.076
  Lysine 2.79 1.20 6.98 0.021
  N-methyl-2-pyridone-5-carboxamide 2.05 0.96 4.51 0.066
  Formate 0.42 0.19 0.94 0.037
IPB (n = 26) N-acetyl glycoprotein fragments 5.84 1.44 39.50 0.028
  Phenylacetylglutamine 0.37 0.09 1.28 0.131
FGR (n = 36) Tyrosine 0.27 0.08 0.81 0.025
  Lactate 0.37 0.12 1.04 0.069
  Alanine 0.38 0.13 1.02 0.064
  Acetate 0.18 0.04 0.60 0.011
  Citrate 0.33 0.09 0.99 0.058
  Trimethylamine 0.14 0.04 0.40 0.001
  Glycine 0.36 0.11 1.02 0.062
  Formate 0.24 0.07 0.71 0.014
SGA (n = 19) Lactate 0.20 0.03 0.89 0.055
  Alanine 0.19 0.03 0.88 0.055
  Acetate 0.12 0.01 0.70 0.050
  N-acetyl neuraminic acid 2.23 0.64 9.10 0.225
  Glycine 0.19 0.03 0.88 0.052
  1. Interquartile odds ratios (IQR, first versus fourth) with 95% confidence interval (CIs) are presented for the incident risk for pregnancy outcomes according to candidate metabolite relative concentrations.
  2. Statistical analysis (z-score) of the beta values (log odds) indicated if the metabolite was significantly contributing to the model (highlighted in bold).
  3. Models were adjusted for maternal education, maternal age, parity and smoking. FGR, fetal growth restriction; IPB, induced preterm birth; SGA, small for gestational age; SPB, spontaneous preterm birth.