Post-diagnostic medication usage | All cancer patients | Cancer patients with available stage/gradec | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cancer specific deaths number (%) | Controls number (%) | Unadjusted OR (95% CI) | P(trenda) | AdjustedbOR (95% CI) | P(trenda) | Unadjusted OR (95% CI) | P(trenda) | Fully adjusted OR (95% CI)d | P(trenda) | |
Breast cancer | ||||||||||
ACEI | ||||||||||
0 (non-user) | 1,192 (83.1) | 5,938 (83.6) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 243 (16.9) | 1,168 (16.4) | 1.04 (0.88, 1.22) | 0.65 | 1.06 (0.89, 1.27) | 0.52 | 0.96 (0.76, 1.21) | 0.72 | 0.83 (0.63, 1.09) | 0.18 |
(0.50) | (0.32) | (0.88) | (0.47) | |||||||
1to 365 DDDs | 92 (6.4) | 469 (6.6) | 0.97 (0.77, 1.23) | 0.80 | 0.96 (0.75, 1.24) | 0.78 | 0.88 (0.61, 1.27) | 0.49 | 0.65 (0.43, 0.99) | 0.04 |
≥365 DDDs | 151 (10.5) | 699 (9.8) | 1.08 (0.89, 1.32) | 0.42 | 1.14 (0.92, 1.41) | 0.25 | 1.01 (0.76, 1.33) | 0.96 | 0.96 (0.69, 1.34) | 0.82 |
ARB | ||||||||||
0 (non-user) | 1,333 (92.9) | 6,602 (92.9) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 102 (7.1) | 504 (7.1) | 1.00 (0.80, 1.26) | 0.98 | 1.06 (0.84, 1.35) | 0.62 | 1.03 (0.84, 1.25) | 0.80 | 0.94 (0.65, 1.37) | 0.75 |
(0.99) | (0.57) | (0.69) | (0.85) | |||||||
1 to 365 DDDs | 33 (2.3) | 160 (2.3) | 1.02 (0.70, 1.51) | 0.87 | 1.01 (0.68, 1.51) | 0.96 | 1.04 (0.58, 1.87) | 0.90 | 0.84 (0.44, 1.61) | 0.59 |
≥365 DDDs | 69 (4.8) | 344 (4.8) | 0.99 (0.75, 1.30) | 0.95 | 1.09 (0.82, 1.45) | 0.55 | 1.08 (0.73, 1.60) | 0.70 | 0.99 (0.64, 1.52) | 0.95 |
Colorectal cancer | ||||||||||
ACEI | ||||||||||
0 (non-user) | 1,231 (81.5) | 5,660 (77.6) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 280 (18.5) | 1,631 (22.4) | 0.79 (0.69, 0.92) | 0.002 | 0.78 (0.66, 0.92) | 0.003 | 0.75 (0.63, 0.89) | 0.001 | 0.76 (0.62, 0.93) | 0.01 |
(0.01) | (0.02) | (0.005) | (0.02) | |||||||
1 to 365 DDDs | 113 (7.5) | 729 (10.0) | 0.72 (0.59, 0.89) | 0.002 | 0.71 (0.57, 0.89) | 0.03 | 0.69 (0.54, 0.90) | 0.005 | 0.71 (0.53, 0.94) | 0.02 |
≥365 DDDs | 167 (11.1) | 902 (12.4) | 0.85 (0.71, 1.02) | 0.09 | 0.84 (0.68, 1.03) | 0.10 | 0.80 (0.64, 0.98) | 0.03 | 0.80 (0.63, 1.02) | 0.07 |
ARB | ||||||||||
0 (non-user) | 1,428 (94.5) | 6,811 (93.4) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 83 (5.5) | 480 (6.6) | 0.84 (0.66, 1.07) | 0.15 | 0.82 (0.64, 1.07) | 0.14 | 0.91 (0.76, 1.08) | 0.29 | 0.80 (0.59, 1.09) | 0.16 |
(0.41) | (0.94) | (0.26) | (0.66) | |||||||
1 to 365 DDDs | 29 (1.9) | 221 (3.0) | 0.64 (0.43, 0.95) | 0.03 | 0.63 (0.42, 0.94) | 0.03 | 0.51 (0.31, 0.83) | 0.01 | 0.61 (0.37, 1.03) | 0.06 |
≥365 DDDs | 54 (3.6) | 259 (3.6) | 1.00 (0.74, 1.36) | 0.98 | 1.00 (0.72, 1.37) | 0.98 | 0.98 (0.69, 1.38) | 0.89 | 0.93 (0.64, 1.36) | 0.72 |
Prostate cancer | ||||||||||
ACEI | ||||||||||
0 (non-user) | 848 (71.6) | 4,145 (70.9) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 336 (28.4) | 1,704 (29.1) | 0.96 (0.83, 1.10) | 0.55 | 0.78 (0.66, 0.92) | 0.003 | 0.98 (0.82, 1.17) | 0.80 | 0.82 (0.67, 1.02) | 0.07 |
(0.47) | (0.003) | (0.85) | (0.11) | |||||||
1 to 365 DDDs | 118 (10.0) | 572 (9.8) | 1.00 (0.81, 1.24) | 0.99 | 0.83 (0.66, 1.04) | 0.11 | 0.96 (0.74, 1.26) | 0.79 | 0.80 (0.59, 1.07) | 0.14 |
≥365 DDDs | 218 (18.4) | 1,132 (19.4) | 0.94 (0.79, 1.11) | 0.44 | 0.75 (0.62, 0.91) | 0.003 | 0.98 (0.80, 1.21) | 0.88 | 0.84 (0.66, 1.07) | 0.16 |
ARB | ||||||||||
0 (non-user) | 1,103 (93.2) | 5,384 (92.1) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 81 (6.8) | 465 (8.0) | 0.86 (0.67, 1.10) | 0.22 | 0.79 (0.61,1.03) | 0.08 | 0.93 (0.70, 1.23) | 0.62 | 0.82 (0.61, 1.11) | 0.21 |
(0.16) | (0.06) | (0.75) | (0.26) | |||||||
1 to 365 DDDs | 30 (2.5) | 153 (2.6) | 0.97 (0.65, 1.44) | 0.88 | 0.88 (0.58, 1.33) | 0.55 | 0.84 (0.52, 1.36) | 0.48 | 0.77 (0.46, 1.29) | 0.33 |
≥365 DDDs | 51 (4.3) | 312 (5.3) | 0.80 (0.59, 1.09) | 0.15 | 0.74 (0.54, 1.02) | 0.07 | 0.98 (0.70, 1.36) | 0.90 | 0.84 (0.59, 1.21) | 0.36 |