Figure 1
From: Molecular determinants of context-dependent progesterone receptor action in breast cancer
Schematic of progesterone receptor structure and select phosphorylation sites. Progesterone receptor (PR) isoforms A and B differ in their inclusion of an N-terminal upstream segment unique to PR-B. Both isoforms contain an identical DNA binding domain (DBD), hinge region (H) and hormone binding domain (HBD). Full-length PR-B contains 14 phosphorylation sites; serines 81, 294, 345 and 400 have known links to PR action and gene expression in breast cancer.