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Table 6 Risk of developing concomitant autoimmune diseases in patients with celiac disease with respect to the presence of anti-MICA autoantibodies, according to age at diagnosis

From: Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients

 

Celiac disease only

Celiac disease with autoimmune diseases

Age groups

Pediatric

Adult

Pediatric

Adult

 

(n = 186)

(n = 139)

(n = 15)

(n = 43)

Anti-MICA-positive

76 (40.9%)

26 (18.7%)

14 (93.3%)

32 (74.4%)

Anti-MICA-negative

110 (59.1%)

113 (81.3%)

1 (6.7%)

11 (25.6%)

Anti-MICA

 

P

Odds ratio

95% confidence interval

Pediatric

 

<0.01

16.28

2.10, 126.34

Adult

 

<0.0001

10.03

4.64, 21.66

  1. Risk associated with the presence of anti-MICA in pediatric (≤14 years) and adult (>14 years) groups.