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Figure 1 | BMC Medicine

Figure 1

From: Epigenetics in the pathogenesis of rheumatoid arthritis

Figure 1

Schematics of epigenome modifiers and chromatin structure. (A) Post-translational modifications on histone tails. Epigenetic signal writers are indicated in red, readers in green, and erasers in blue. Acetylated lysine residues are represented by green rectangles, methylated lysines by blue triangles and methylated CpGs of genomic DNA by magenta circles. (B) States of the chromatin and associated histone and DNA marks. The figure is original, with some elements adapted from [10]. DNMTs, DNA methyltransferases; HATs, histone acetyltranferases; HDACs, histone deacetylases; MBD, methyl-CpG-binding domain; TET, ten-eleven translocation; TF, transcription factor.

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