HIV infections averted and incremental costs versus the status quo with 100% scale-up for single or combination programs over 20 years. (A) Infections averted over 20 years with 100% scale-up for single or combination programs. (B) Incremental costs versus status quo over 20 years with 100% scale-up for single or combination programs. Strategies include: Guidelines ART (individuals with CD4 cell counts ≤350 cells/μL only), Universal ART (all HIV-infected individuals), General PrEP (general population), and Focused PrEP (individuals at high risk of acquiring HIV). Bars 1 and 2 show results of ART programs alone, 3 and 4 show results of PrEP programs alone, and bars 5 to 8 show results of pairwise combinations of ART and PrEP programs. ART strategies indicated by bar color: Guidelines - red; Universal - orange; Status quo - no color. PrEP strategies indicated by bar outline: General - solid line; Focused - dashed line; Status quo - no line.