Cost-effectiveness (quality-adjusted life-years versus total costs over 20 years) of 100% scale-up for single or combination programs. Guidelines ART (individuals with CD4 cell counts ≤350 cells/μL only), Universal ART (all HIV-infected individuals), General PrEP (general population), Focused PrEP (individuals at high risk of acquiring HIV). ART strategies indicated by dot shape: Guidelines - triangle; Universal - diamond; Status quo - X mark. PrEP strategies indicated by dot color: General - black; Focused - gray. There is no PrEP in the status quo.