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Table 1 Diagnostic performance of various anti-citrullinated protein/peptide antibodies assays in rheumatoid arthritis

From: Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis?

  Sensitivity (%) Specificity (%) Supplementary information Ref.
CCP 60 to 80 95 to 99 - High significant predictive value [11, 21]
- Anti-CCP is a constant feature of RA with 5% changes in disease course
CCP1 44 to 56 90 to 97 - Peptide from filaggrin protein [22]
CCP2 60 to 80 96 to 98 - Artificially optimized peptide [21, 22, 24]
- Positive in 20 to 30% of RF-negative RA patients
CCP3 61 to 83 93 to 98 - Artificially optimized peptide [2224]
- In early and RF-neg RA patients more prevalent, with higher sensitivity/specificity then CCP2 assays
CCP3.1 54 to 70 94 to 99 - FDA approved for early detection of RA [23]
MCV 60 to 69 87 to 98 - Similar diagnostic performance as CCP2 [21, 23, 24]
- Useful in RF-neg, anti-CCP-neg RA patients
- 10% of CCP-neg and 30% of IgM RF-neg RA patients are MCV positive
    - Simultaneous CCP and MCV assessment improves RA diagnostics to ca. 98%  
  1. CCP, cyclic citrullinated peptides; MCV, modified citrullinated vimentin; RA, rheumatoid arthritis; RF, rheumatoid factor.