|
Myopathy
|
|
Gaist et al.[50]
|
2.30
|
2.10
|
One prescription and additional 30 days supply
|
Medical codes for myopathic events and validation by independent blind review of medical records
|
|
(1.20 to 4.40)
|
|
Hippisley-Cox et al.[55]
|
0.26%
|
0.22%
|
First prescription after January 2002
|
Medical codes for moderate or serious myopathic events (myopathy or rhabdomyolysis or a CK ≥4X ULN)
|
|
(0.24% to 0.28%)
| |
|
McClure et al.[77]
|
9.06
|
5.77
|
One prescription during the study period
|
Medical codes for myopathy and CK ≥10X ULN
|
|
(n.r.)
|
|
Smeeth et al.[94]
|
0.11%
|
0.08%
|
First prescription after January 1995
|
Medical codes for myositis or myolysis
|
|
(n.r.)
|
|
Hepatic disorder
|
|
Hippisley-Cox et al.[55]
|
1.20%
|
0.50%
|
First prescription after January 2002
|
ALT ≥120 IU/l among patients without chronic liver disease
|
|
(1.13% to 1.22%)
| |
|
Smeeth et al.[94]
|
1.60%
|
0.30%
|
First prescription after January 1995
|
Medical codes for acute liver disease
|
|
First year only
|
0.44%
|
0.16%
|
|
(n.r.)
|
|
Diabetes
|
|
Culver et al.[41]
|
6.25%
|
2.25%
|
One prescription at the first screening interview and three-year follow-up
|
Self-report of a new physician diagnosis of treated diabetes
|
|
(5.71% to 6.84%)
|
|
Jick et al.[59]
|
n.a.
|
n.a.
|
Two prescriptions one year before index date
|
Medical code for first diagnosis of diabetes plus more than two prescriptions for a hypoglycaemic agent or three records of diet management
|
