Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia

Table 2 Volume, timing and additional transfusion by study arm

	Arm A: 20 ml/kg (Number = 82)	Arm B: 30 ml/kg (Number = 78)	Pvalue
Volume of initial transfusion^a (ml/kg) – median (IQR)	20 (20 to 20)	30 (30 to 30)	<0.0001
Rate of initial transfusion^a (ml/kg/hr) – median (IQR)	5.7 (4.9 to 6.7)	7.6 (6.1 to 8.4)	<0.0001
Time to initial transfusion (minutes) – median (IQR)	95 (75 to 128)	103 (75 to 130)	0.74
Total volume tranfused 0 to 48 hours (ml/kg) – median (IQR)	20 (20 to 20)	30 (30 to 30)	<0.0001
Number of transfusions^b per child 0 to 48 hours, number (%)			0.23
1	67 (82)	69 (88)
2	14 (17)	8 (10)
3	0 (0)	1 (1)
4	1 (1)	0(0)
Number of children with a transfusion after 48 hours	2	1

^aRefers to blood infused before the first 30-minute break between aliquots of blood. This was the entire initial prescription for all but three children (all 30 ml/kg arm) where the last aliquot was given 49, 64, and 92 minutes after the previous aliquot; ^brefers to the number of prescriptions. IQR, interquartile range.

ISSN: 1741-7015