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Table 2 Summary of studies examining the interaction between life stress and brain-derived neurotrophic factor ( BDNF ) Val66Met in depression

From: Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis

Source

N

Females,%

Age at study assessment (Mean or range)

Ancestry

Study design

Stressor

Life stress assessment

Outcome

Averaged one-sided Pvalue

Kaufman et al., 2006 [79]

194

51

9.3 years

Mixed

Cross-sectional

Childhood adversity

Children taken into care

Depressive symptoms

0.6765

Kim et al., 2007 [43]

732

59

65 years and over

East Asian

Cross-sectional

Stressful life events

Researcher-administered questionnaire

Depression diagnosis

0.000315

Wichers et al., 2008 [73]

464

100

18 to 46 years

European

Longitudinal twin study

Childhood adversity

Questionnaire

Depressive symptoms

0.009

Aguilera et al., 2009 [66]

470

55

22.9 years

European

Cross-sectional

Childhood adversity

Questionnaire

Depressive symptoms

0.637

Bukh et al., 2009 [82]

290

66

38.5 years (median)

European

Case only

Stressful life events

Interview

Depression onset

0.004

Gatt et al., 2009 [88]

374

51

36.2 years

European

Cross-sectional

Childhood adversity

Questionnaire

Depressive symptoms

0.272

Hosang et al., 2010 [75]

1,085

62

37.83 years

European

Case–control

Stressful life events

Researcher-administered questionnaire

Bipolar disorder relapse

0.02

Lavebratt et al., 2010 [68]

950

58

20 to 64 years

European

Longitudinal survey

Childhood adversity and Stressful life events

Questionnaire

Depressive diagnosis

0.5

Nederhof et al., 2010 [80]

1,096

53

16.13 years

European

Longitudinal study

Childhood adversity

Questionnaires and interviews

Depressive symptoms

0.3525

Carver et al., 2011 [76]

133

74

18.71 years

Mixed

Cross-sectional

Childhood adversity

Questionnaire

Depression diagnosis

0.01

Elzinga et al., 2011 [81]

1,435

69

42.2 years

European

Case only

Childhood adversity and stressful life events

Interview

Depression diagnosis and symptom severity

0.4325

Juhasz et al., 2011 [74]

1,269

70

34.04 years

Caucasian

Cross-sectional

Childhood adversity and stressful life events

Questionnaire

Depression diagnosis

0.13165

Chen et al., 2012 [69]a

780

51

13.6 years

Han Chinese

Longitudinal twin study

Stressful life events

Questionnaire

Depressive symptoms

0.9875

Grabe et al., 2012 [70]a

2,035

53

55.6 years

Caucasian

Case only

Childhood adversity

Questionnaire

Depressive symptoms

0.785

Herbert et al., 2012 [83]

279

100

36.8 years

Caucasian

Longitudinal study

Stressful life events

Interview

Depression diagnosis

0.0935

Perea et al., 2012 [77]

302

50

18 years

Mixed (Columbian population)

Cross-sectional

Childhood adversity and stressful life events

Questionnaire

Depressive symptoms

0.01725

Quinn et al., 2012 [65]

240

59

40.01 years

Unknown

Cross-sectional

Childhood adversity

Questionnaire

Melancholic subtype of depression diagnosis

0.5

Caldwell et al., 2013 [71]a

124

66

21.97 years

Mixed

Cross-sectional

Childhood adversity

Questionnaire

Depressive symptoms

0.8705

Comasco et al., 2013 [67]

1,393

50

17 to 18 years

European

Cross-sectional

Childhood adversity

Questionnaire

Depressive symptoms

0.251

La Greca et al., 2013 [78]

116

54

8.85 years

Mixed

Cross-sectional

Childhood adversity

Questionnaire

Depressive symptoms

0.167833

Jiang et al., 2013 [89]a

238

73

61.7 years

Caucasians

Cross-sectional

Stressful life events

Carer of person with dementia

Depressive symptoms

0.9805

Brown et al., 2013 [85]

234

100

37 years

Caucasian

Longitudinal study

Childhood adversity and stressful life events

Interview

Depressive episode onset

0.431

Total

14,233

        

Average sample size

647

       

0.03

  1. aTested Val recessive model.