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Figure 3 | BMC Medicine

Figure 3

From: The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder

Figure 3

Venn diagram showing the number of genes overlapping across all rodent studies. Only 67 genes were differentially regulated in response to both early (MS) and late stressors (UCMS) pointing at minimal genetic overlap. However, many of these genes (approximately 30%) were also differentially regulated in an endogenous rat model of depression. The replication of these genes in a different organism that shows congenital depression-like symptoms, points at molecular mechanisms that may be involved in the human pathology.

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BMC Medicine

ISSN: 1741-7015

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